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Nonspecificity in a nonimmune human scFv repertoire

Efforts to develop effective antibody therapeutics are frequently hampered by issues such as aggregation and nonspecificity, often only detected in late stages of the development process. In this study, we used a high throughput cross-reactivity assay to select nonspecific clones from a naïve human...

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Detalles Bibliográficos
Autores principales: Kelly, Ryan L., Zhao, Jessie, Le, Doris, Wittrup, K. Dane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627588/
https://www.ncbi.nlm.nih.gov/pubmed/28910564
http://dx.doi.org/10.1080/19420862.2017.1356528

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