Functional optimization of agonistic antibodies to OX40 receptor with novel Fc mutations to promote antibody multimerization

Immunostimulatory receptors belonging to the tumor necrosis factor receptor (TNFR) superfamily are emerging as promising targets for cancer immunotherapies. To optimize the agonism of therapeutic antibodies to these receptors, Fc engineering of antibodies was applied to facilitate the clustering of...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Di, Armstrong, Anthony A., Tam, Susan H., McCarthy, Stephen G., Luo, Jinquan, Gilliland, Gary L., Chiu, Mark L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627589/
https://www.ncbi.nlm.nih.gov/pubmed/28758875
http://dx.doi.org/10.1080/19420862.2017.1358838

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627589/
https://www.ncbi.nlm.nih.gov/pubmed/28758875
http://dx.doi.org/10.1080/19420862.2017.1358838

Ejemplares similares