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Functional optimization of agonistic antibodies to OX40 receptor with novel Fc mutations to promote antibody multimerization
Immunostimulatory receptors belonging to the tumor necrosis factor receptor (TNFR) superfamily are emerging as promising targets for cancer immunotherapies. To optimize the agonism of therapeutic antibodies to these receptors, Fc engineering of antibodies was applied to facilitate the clustering of...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627589/ https://www.ncbi.nlm.nih.gov/pubmed/28758875 http://dx.doi.org/10.1080/19420862.2017.1358838 |