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Social-group identity and population substructure in admixed populations in New Mexico and Latin America

We examined the relationship between continental-level genetic ancestry and racial and ethnic identity in an admixed population in New Mexico with the goal of increasing our understanding of how racial and ethnic identity influence genetic substructure in admixed populations. Our sample consists of...

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Autores principales: Healy, Meghan E., Hill, Deirdre, Berwick, Marianne, Edgar, Heather, Gross, Jessica, Hunley, Keith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627912/
https://www.ncbi.nlm.nih.gov/pubmed/28977000
http://dx.doi.org/10.1371/journal.pone.0185503
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author Healy, Meghan E.
Hill, Deirdre
Berwick, Marianne
Edgar, Heather
Gross, Jessica
Hunley, Keith
author_facet Healy, Meghan E.
Hill, Deirdre
Berwick, Marianne
Edgar, Heather
Gross, Jessica
Hunley, Keith
author_sort Healy, Meghan E.
collection PubMed
description We examined the relationship between continental-level genetic ancestry and racial and ethnic identity in an admixed population in New Mexico with the goal of increasing our understanding of how racial and ethnic identity influence genetic substructure in admixed populations. Our sample consists of 98 New Mexicans who self-identified as Hispanic or Latino (NM-HL) and who further categorized themselves by race and ethnic subgroup membership. The genetic data consist of 270 newly-published autosomal microsatellites from the NM-HL sample and previously published data from 57 globally distributed populations, including 13 admixed samples from Central and South America. For these data, we 1) summarized the major axes of genetic variation using principal component analyses, 2) performed tests of Hardy Weinberg equilibrium, 3) compared empirical genetic ancestry distributions to those predicted under a model of admixture that lacked substructure, 4) tested the hypotheses that individuals in each sample had 100%, 0%, and the sample-mean percentage of African, European, and Native American ancestry. We found that most NM-HL identify themselves and their parents as belonging to one of two groups, conforming to a region-specific narrative that distinguishes recent immigrants from Mexico from individuals whose families have resided in New Mexico for generations and who emphasize their Spanish heritage. The “Spanish” group had significantly lower Native American ancestry and higher European ancestry than the “Mexican” group. Positive F(IS) values, PCA plots, and heterogeneous ancestry distributions suggest that most Central and South America admixed samples also contain substructure, and that this substructure may be related to variation in social identity. Genetic substructure appears to be common in admixed populations in the Americas and may confound attempts to identify disease-causing genes and to understand the social causes of variation in health outcomes and social inequality.
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spelling pubmed-56279122017-10-20 Social-group identity and population substructure in admixed populations in New Mexico and Latin America Healy, Meghan E. Hill, Deirdre Berwick, Marianne Edgar, Heather Gross, Jessica Hunley, Keith PLoS One Research Article We examined the relationship between continental-level genetic ancestry and racial and ethnic identity in an admixed population in New Mexico with the goal of increasing our understanding of how racial and ethnic identity influence genetic substructure in admixed populations. Our sample consists of 98 New Mexicans who self-identified as Hispanic or Latino (NM-HL) and who further categorized themselves by race and ethnic subgroup membership. The genetic data consist of 270 newly-published autosomal microsatellites from the NM-HL sample and previously published data from 57 globally distributed populations, including 13 admixed samples from Central and South America. For these data, we 1) summarized the major axes of genetic variation using principal component analyses, 2) performed tests of Hardy Weinberg equilibrium, 3) compared empirical genetic ancestry distributions to those predicted under a model of admixture that lacked substructure, 4) tested the hypotheses that individuals in each sample had 100%, 0%, and the sample-mean percentage of African, European, and Native American ancestry. We found that most NM-HL identify themselves and their parents as belonging to one of two groups, conforming to a region-specific narrative that distinguishes recent immigrants from Mexico from individuals whose families have resided in New Mexico for generations and who emphasize their Spanish heritage. The “Spanish” group had significantly lower Native American ancestry and higher European ancestry than the “Mexican” group. Positive F(IS) values, PCA plots, and heterogeneous ancestry distributions suggest that most Central and South America admixed samples also contain substructure, and that this substructure may be related to variation in social identity. Genetic substructure appears to be common in admixed populations in the Americas and may confound attempts to identify disease-causing genes and to understand the social causes of variation in health outcomes and social inequality. Public Library of Science 2017-10-04 /pmc/articles/PMC5627912/ /pubmed/28977000 http://dx.doi.org/10.1371/journal.pone.0185503 Text en © 2017 Healy et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Healy, Meghan E.
Hill, Deirdre
Berwick, Marianne
Edgar, Heather
Gross, Jessica
Hunley, Keith
Social-group identity and population substructure in admixed populations in New Mexico and Latin America
title Social-group identity and population substructure in admixed populations in New Mexico and Latin America
title_full Social-group identity and population substructure in admixed populations in New Mexico and Latin America
title_fullStr Social-group identity and population substructure in admixed populations in New Mexico and Latin America
title_full_unstemmed Social-group identity and population substructure in admixed populations in New Mexico and Latin America
title_short Social-group identity and population substructure in admixed populations in New Mexico and Latin America
title_sort social-group identity and population substructure in admixed populations in new mexico and latin america
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627912/
https://www.ncbi.nlm.nih.gov/pubmed/28977000
http://dx.doi.org/10.1371/journal.pone.0185503
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