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Isn’t there an inductance factor in the plasma membrane of nerves?

It is established knowledge that the action potential event of nerves is formed by the combination of a phasic inward Na(+) current and a following outward K(+) current which increases gradually. These changes in current are commonly referred to as conductance changes of channels for Na(+) and K(+)...

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Autor principal: Kumai, Toshifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society of Japan (BSJ) 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627987/
https://www.ncbi.nlm.nih.gov/pubmed/28989835
http://dx.doi.org/10.2142/biophysico.14.0_147
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author Kumai, Toshifumi
author_facet Kumai, Toshifumi
author_sort Kumai, Toshifumi
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description It is established knowledge that the action potential event of nerves is formed by the combination of a phasic inward Na(+) current and a following outward K(+) current which increases gradually. These changes in current are commonly referred to as conductance changes of channels for Na(+) and K(+) with time. On the other hand, electric requirements for action potential generation in phenomena such as anode break excitation, hyperpolarizing break stimulation and accommodation, strongly suggest an existence of an inductance factor in the plasma membrane of nerves. In this study, the possibility that the Na(+) channel could be simulated by a circuit composed serially of resistance (R), inductance (L), and capacitance (C) was examined using a computer simulation. Electric responses of the RLC circuit (R(2)/4L(2) ≥ 1/LC) to step voltages are as followings: (1) A transient potential is produced on the inductor, (2) the circuit current simulates well the Na(+) current manner, and (3) time course of the capacitor potential resembles the K(+) current change.
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spelling pubmed-56279872017-10-06 Isn’t there an inductance factor in the plasma membrane of nerves? Kumai, Toshifumi Biophys Physicobiol Regular Article It is established knowledge that the action potential event of nerves is formed by the combination of a phasic inward Na(+) current and a following outward K(+) current which increases gradually. These changes in current are commonly referred to as conductance changes of channels for Na(+) and K(+) with time. On the other hand, electric requirements for action potential generation in phenomena such as anode break excitation, hyperpolarizing break stimulation and accommodation, strongly suggest an existence of an inductance factor in the plasma membrane of nerves. In this study, the possibility that the Na(+) channel could be simulated by a circuit composed serially of resistance (R), inductance (L), and capacitance (C) was examined using a computer simulation. Electric responses of the RLC circuit (R(2)/4L(2) ≥ 1/LC) to step voltages are as followings: (1) A transient potential is produced on the inductor, (2) the circuit current simulates well the Na(+) current manner, and (3) time course of the capacitor potential resembles the K(+) current change. The Biophysical Society of Japan (BSJ) 2017-09-14 /pmc/articles/PMC5627987/ /pubmed/28989835 http://dx.doi.org/10.2142/biophysico.14.0_147 Text en 2017 © The Biophysical Society of Japan
spellingShingle Regular Article
Kumai, Toshifumi
Isn’t there an inductance factor in the plasma membrane of nerves?
title Isn’t there an inductance factor in the plasma membrane of nerves?
title_full Isn’t there an inductance factor in the plasma membrane of nerves?
title_fullStr Isn’t there an inductance factor in the plasma membrane of nerves?
title_full_unstemmed Isn’t there an inductance factor in the plasma membrane of nerves?
title_short Isn’t there an inductance factor in the plasma membrane of nerves?
title_sort isn’t there an inductance factor in the plasma membrane of nerves?
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627987/
https://www.ncbi.nlm.nih.gov/pubmed/28989835
http://dx.doi.org/10.2142/biophysico.14.0_147
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