Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension

Neurohormonal overactivation plays an important role in pulmonary hypertension (PH). In this context, renal denervation, which aims to inhibit the neurohormonal systems, may be a promising adjunct therapy in PH. In this proof-of-concept study, we have demonstrated in 2 experimental models of PH that...

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Autores principales: da Silva Gonçalves Bos, Denielli, Happé, Chris, Schalij, Ingrid, Pijacka, Wioletta, Paton, Julian F.R., Guignabert, Christophe, Tu, Ly, Thuillet, Raphaël, Bogaard, Harm-Jan, van Rossum, Albert C., Vonk-Noordegraaf, Anton, de Man, Frances S., Handoko, M. Louis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
PRECLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628179/
https://www.ncbi.nlm.nih.gov/pubmed/29034356
http://dx.doi.org/10.1016/j.jacbts.2016.09.007
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author da Silva Gonçalves Bos, Denielli
Happé, Chris
Schalij, Ingrid
Pijacka, Wioletta
Paton, Julian F.R.
Guignabert, Christophe
Tu, Ly
Thuillet, Raphaël
Bogaard, Harm-Jan
van Rossum, Albert C.
Vonk-Noordegraaf, Anton
de Man, Frances S.
Handoko, M. Louis
author_facet da Silva Gonçalves Bos, Denielli
Happé, Chris
Schalij, Ingrid
Pijacka, Wioletta
Paton, Julian F.R.
Guignabert, Christophe
Tu, Ly
Thuillet, Raphaël
Bogaard, Harm-Jan
van Rossum, Albert C.
Vonk-Noordegraaf, Anton
de Man, Frances S.
Handoko, M. Louis
author_sort da Silva Gonçalves Bos, Denielli
collection PubMed
description Neurohormonal overactivation plays an important role in pulmonary hypertension (PH). In this context, renal denervation, which aims to inhibit the neurohormonal systems, may be a promising adjunct therapy in PH. In this proof-of-concept study, we have demonstrated in 2 experimental models of PH that renal denervation delayed disease progression, reduced pulmonary vascular remodeling, lowered right ventricular afterload, and decreased right ventricular diastolic stiffness, most likely by suppression of the renin-angiotensin-aldosterone system.
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spelling pubmed-56281792017-10-11 Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension da Silva Gonçalves Bos, Denielli Happé, Chris Schalij, Ingrid Pijacka, Wioletta Paton, Julian F.R. Guignabert, Christophe Tu, Ly Thuillet, Raphaël Bogaard, Harm-Jan van Rossum, Albert C. Vonk-Noordegraaf, Anton de Man, Frances S. Handoko, M. Louis JACC Basic Transl Sci PRECLINICAL RESEARCH Neurohormonal overactivation plays an important role in pulmonary hypertension (PH). In this context, renal denervation, which aims to inhibit the neurohormonal systems, may be a promising adjunct therapy in PH. In this proof-of-concept study, we have demonstrated in 2 experimental models of PH that renal denervation delayed disease progression, reduced pulmonary vascular remodeling, lowered right ventricular afterload, and decreased right ventricular diastolic stiffness, most likely by suppression of the renin-angiotensin-aldosterone system. Elsevier 2017-02-01 /pmc/articles/PMC5628179/ /pubmed/29034356 http://dx.doi.org/10.1016/j.jacbts.2016.09.007 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle PRECLINICAL RESEARCH
da Silva Gonçalves Bos, Denielli
Happé, Chris
Schalij, Ingrid
Pijacka, Wioletta
Paton, Julian F.R.
Guignabert, Christophe
Tu, Ly
Thuillet, Raphaël
Bogaard, Harm-Jan
van Rossum, Albert C.
Vonk-Noordegraaf, Anton
de Man, Frances S.
Handoko, M. Louis
Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension
title Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension
title_full Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension
title_fullStr Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension
title_full_unstemmed Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension
title_short Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension
title_sort renal denervation reduces pulmonary vascular remodeling and right ventricular diastolic stiffness in experimental pulmonary hypertension
topic PRECLINICAL RESEARCH
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628179/
https://www.ncbi.nlm.nih.gov/pubmed/29034356
http://dx.doi.org/10.1016/j.jacbts.2016.09.007
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