A rare case of CD1a‐negative Langerhans cell histiocytosis of the central nervous system in a child

Langerhans cell histiocytosis is a dendritic cell disorder with a wide spectrum of severity and presentations. Histopathology typically demonstrates a proliferation of Langerhans cells and a lymphohistiocytic inflammatory infiltrate with eosinophils. The diagnosis is supported by immunohistochemistr...

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Detalles Bibliográficos
Autores principales: Powell, Priscilla, Vitug, Gaile, Castro‐Silva, Fernando, Ray, Anish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628212/
https://www.ncbi.nlm.nih.gov/pubmed/29026568
http://dx.doi.org/10.1002/ccr3.1136
Descripción
Sumario:Langerhans cell histiocytosis is a dendritic cell disorder with a wide spectrum of severity and presentations. Histopathology typically demonstrates a proliferation of Langerhans cells and a lymphohistiocytic inflammatory infiltrate with eosinophils. The diagnosis is supported by immunohistochemistry with the cell markers S100, CD1a, CD68, and Langerin [Blood, 126, 2015, 26 and N Engl J Med, 331, 1994, 154].

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