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Bacterial flagellin—a potent immunomodulatory agent

Flagellin is a subunit protein of the flagellum, a whip-like appendage that enables bacterial motility. Traditionally, flagellin was viewed as a virulence factor that contributes to the adhesion and invasion of host cells, but now it has emerged as a potent immune activator, shaping both the innate...

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Detalles Bibliográficos
Autores principales: Hajam, Irshad A, Dar, Pervaiz A, Shahnawaz, Imam, Jaume, Juan Carlos, Lee, John Hwa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628280/
https://www.ncbi.nlm.nih.gov/pubmed/28860663
http://dx.doi.org/10.1038/emm.2017.172
Descripción
Sumario:Flagellin is a subunit protein of the flagellum, a whip-like appendage that enables bacterial motility. Traditionally, flagellin was viewed as a virulence factor that contributes to the adhesion and invasion of host cells, but now it has emerged as a potent immune activator, shaping both the innate and adaptive arms of immunity during microbial infections. In this review, we summarize our understanding of bacterial flagellin and host immune system interactions and the role flagellin as an adjuvant, anti-tumor and radioprotective agent, and we address important areas of future research interests.