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Computational investigation of O(2) diffusion through an intra-molecular tunnel in AlkB; influence of polarization on O(2) transport
E. Coli AlkB catalyzes the direct dealkylation of various alkylated bases in damaged DNA. The diffusion of molecular oxygen to the active site in AlkB is an essential step for the oxidative dealkylation activity. Despite detailed studies on the stepwise oxidation mechanism of AlkB, there is no concl...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Royal Society of Chemistry
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628400/ https://www.ncbi.nlm.nih.gov/pubmed/28989656 http://dx.doi.org/10.1039/c7sc00997f |