The CNS in inbred transgenic models of 4-repeat Tauopathy develops consistent tau seeding capacity yet focal and diverse patterns of protein deposition

BACKGROUND: MAPT mutations cause neurodegenerative diseases such as frontotemporal dementia but, strikingly, patients with the same mutation may have different clinical phenotypes. METHODS: Given heterogeneities observed in a transgenic (Tg) mouse line expressing low levels of human (2 N, 4R) P301L...

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Detalles Bibliográficos
Autores principales: Eskandari-Sedighi, Ghazaleh, Daude, Nathalie, Gapeshina, Hristina, Sanders, David W., Kamali-Jamil, Razieh, Yang, Jing, Shi, Beipei, Wille, Holger, Ghetti, Bernardino, Diamond, Marc I., Janus, Christopher, Westaway, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628424/
https://www.ncbi.nlm.nih.gov/pubmed/28978354
http://dx.doi.org/10.1186/s13024-017-0215-7

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