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Effects of cyclic parenteral nutrition on parenteral-associated liver dysfunction parameters

INTRODUCTION: One of the most common complications of parenteral nutrition (PN) is liver dysfunction (LD). Therapeutic approaches for LD include, among others, administering cyclic parenteral nutrition (cPN), allowing some hours for metabolic rest. The purpose of this study was to evaluate the effec...

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Autores principales: Arenas Villafranca, Jose J., Nieto Guindo, Miriam, Álvaro Sanz, Elena, Moreno Santamaria, Manuela, Garrido Siles, Marga, Abilés, Jimena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628441/
https://www.ncbi.nlm.nih.gov/pubmed/28978317
http://dx.doi.org/10.1186/s12937-017-0289-7
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author Arenas Villafranca, Jose J.
Nieto Guindo, Miriam
Álvaro Sanz, Elena
Moreno Santamaria, Manuela
Garrido Siles, Marga
Abilés, Jimena
author_facet Arenas Villafranca, Jose J.
Nieto Guindo, Miriam
Álvaro Sanz, Elena
Moreno Santamaria, Manuela
Garrido Siles, Marga
Abilés, Jimena
author_sort Arenas Villafranca, Jose J.
collection PubMed
description INTRODUCTION: One of the most common complications of parenteral nutrition (PN) is liver dysfunction (LD). Therapeutic approaches for LD include, among others, administering cyclic parenteral nutrition (cPN), allowing some hours for metabolic rest. The purpose of this study was to evaluate the effectiveness of cPN in treating PN-associated LD. MATERIALS AND METHODS: A retrospective observational study was carried out at the Costa del Sol Hospital in Spain between 2013 and 2014. The study involved inpatients ≥18 years old prescribed with cPN due to the development of PN-associated LD. The hepatic biochemical parameters measured at baseline and after completion of cPN included aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyltransferase (GGT), alkaline phosphatase (ALP) and total bilirubin (TB). Quantitative values (age, biochemical parameters) were compared using matched Student’s t-test; the mean change in qualitative variables (sex, indication of PN, hepatic comorbidities, presence of insulin in cPN, infection during cPN, management of LD prior to cPN administrarion) was estimated using Mann-Whitney U test, and bivariate correlation between quantitative variables was determined by Spearman’s coefficient of correlation. RESULTS: Thirty-seven patients met inclusion criteria. All hepatic function parameters except ALP improved after the administration of cPN, with statistically significant differences (p < 0.05) in AST GGT and TB. CONCLUSION: cPN improves PN-associated LD by restoring abnormal AST, GGT, and BT levels to normal, and reducing ALT levels close to normal. The results obtained suggest that the administration of cPN is effective in reverting PN-associated LD.
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spelling pubmed-56284412017-10-13 Effects of cyclic parenteral nutrition on parenteral-associated liver dysfunction parameters Arenas Villafranca, Jose J. Nieto Guindo, Miriam Álvaro Sanz, Elena Moreno Santamaria, Manuela Garrido Siles, Marga Abilés, Jimena Nutr J Research INTRODUCTION: One of the most common complications of parenteral nutrition (PN) is liver dysfunction (LD). Therapeutic approaches for LD include, among others, administering cyclic parenteral nutrition (cPN), allowing some hours for metabolic rest. The purpose of this study was to evaluate the effectiveness of cPN in treating PN-associated LD. MATERIALS AND METHODS: A retrospective observational study was carried out at the Costa del Sol Hospital in Spain between 2013 and 2014. The study involved inpatients ≥18 years old prescribed with cPN due to the development of PN-associated LD. The hepatic biochemical parameters measured at baseline and after completion of cPN included aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyltransferase (GGT), alkaline phosphatase (ALP) and total bilirubin (TB). Quantitative values (age, biochemical parameters) were compared using matched Student’s t-test; the mean change in qualitative variables (sex, indication of PN, hepatic comorbidities, presence of insulin in cPN, infection during cPN, management of LD prior to cPN administrarion) was estimated using Mann-Whitney U test, and bivariate correlation between quantitative variables was determined by Spearman’s coefficient of correlation. RESULTS: Thirty-seven patients met inclusion criteria. All hepatic function parameters except ALP improved after the administration of cPN, with statistically significant differences (p < 0.05) in AST GGT and TB. CONCLUSION: cPN improves PN-associated LD by restoring abnormal AST, GGT, and BT levels to normal, and reducing ALT levels close to normal. The results obtained suggest that the administration of cPN is effective in reverting PN-associated LD. BioMed Central 2017-10-04 /pmc/articles/PMC5628441/ /pubmed/28978317 http://dx.doi.org/10.1186/s12937-017-0289-7 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Arenas Villafranca, Jose J.
Nieto Guindo, Miriam
Álvaro Sanz, Elena
Moreno Santamaria, Manuela
Garrido Siles, Marga
Abilés, Jimena
Effects of cyclic parenteral nutrition on parenteral-associated liver dysfunction parameters
title Effects of cyclic parenteral nutrition on parenteral-associated liver dysfunction parameters
title_full Effects of cyclic parenteral nutrition on parenteral-associated liver dysfunction parameters
title_fullStr Effects of cyclic parenteral nutrition on parenteral-associated liver dysfunction parameters
title_full_unstemmed Effects of cyclic parenteral nutrition on parenteral-associated liver dysfunction parameters
title_short Effects of cyclic parenteral nutrition on parenteral-associated liver dysfunction parameters
title_sort effects of cyclic parenteral nutrition on parenteral-associated liver dysfunction parameters
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628441/
https://www.ncbi.nlm.nih.gov/pubmed/28978317
http://dx.doi.org/10.1186/s12937-017-0289-7
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