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Effect of a Low-Calorie Diet on Restoration of Normoglycemia in Obese subjects with Type 2 Diabetes

INTRODUCTION: Type 2 diabetes mellitus (T2DM) is considered to be an inevitably progressive disease. Complex therapies add to the financial and psychological burden. Very low-calorie diets (LCDs) are emerging as an option in the management of type 2 diabetes. METHODS: We performed a clinical audit o...

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Autores principales: Bhatt, Anjali Amit, Choudhari, Priya K., Mahajan, Rutuja R., Sayyad, Mehmood G., Pratyush, Devi D., Hasan, Imtiaz, Javherani, Rajesh S., Bothale, Manish M., Purandare, Vedavati B., Unnikrishnan, Ambika Gopalakrishnan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628553/
https://www.ncbi.nlm.nih.gov/pubmed/28989891
http://dx.doi.org/10.4103/ijem.IJEM_206_17
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author Bhatt, Anjali Amit
Choudhari, Priya K.
Mahajan, Rutuja R.
Sayyad, Mehmood G.
Pratyush, Devi D.
Hasan, Imtiaz
Javherani, Rajesh S.
Bothale, Manish M.
Purandare, Vedavati B.
Unnikrishnan, Ambika Gopalakrishnan
author_facet Bhatt, Anjali Amit
Choudhari, Priya K.
Mahajan, Rutuja R.
Sayyad, Mehmood G.
Pratyush, Devi D.
Hasan, Imtiaz
Javherani, Rajesh S.
Bothale, Manish M.
Purandare, Vedavati B.
Unnikrishnan, Ambika Gopalakrishnan
author_sort Bhatt, Anjali Amit
collection PubMed
description INTRODUCTION: Type 2 diabetes mellitus (T2DM) is considered to be an inevitably progressive disease. Complex therapies add to the financial and psychological burden. Very low-calorie diets (LCDs) are emerging as an option in the management of type 2 diabetes. METHODS: We performed a clinical audit of patients with T2DM who received 12 weeks of LCD. RESULTS: This case series documents that 6 out of 12 participants (median baseline HbA1c 9%) achieved HbA1c level in nondiabetes range with LCD despite stopping all antidiabetes medications. There was an improvement in serum triglycerides, HDL cholesterol, total cholesterol, C-Reactive protein, urine microalbumin, liver transaminases, liver fat and the indices of insulin resistance, beta cell secretory capacity, and insulin sensitivity. CONCLUSION: If long-term follow-up proves sustained benefits, such dietary restriction may be an alternative to more drastic options for reversal of type 2 diabetes. This may also help in changing the treatment perspective of a newly detected T2DM from an incurable and inevitably progressive disease to a potentially reversible disease.
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spelling pubmed-56285532017-10-06 Effect of a Low-Calorie Diet on Restoration of Normoglycemia in Obese subjects with Type 2 Diabetes Bhatt, Anjali Amit Choudhari, Priya K. Mahajan, Rutuja R. Sayyad, Mehmood G. Pratyush, Devi D. Hasan, Imtiaz Javherani, Rajesh S. Bothale, Manish M. Purandare, Vedavati B. Unnikrishnan, Ambika Gopalakrishnan Indian J Endocrinol Metab Brief Communication INTRODUCTION: Type 2 diabetes mellitus (T2DM) is considered to be an inevitably progressive disease. Complex therapies add to the financial and psychological burden. Very low-calorie diets (LCDs) are emerging as an option in the management of type 2 diabetes. METHODS: We performed a clinical audit of patients with T2DM who received 12 weeks of LCD. RESULTS: This case series documents that 6 out of 12 participants (median baseline HbA1c 9%) achieved HbA1c level in nondiabetes range with LCD despite stopping all antidiabetes medications. There was an improvement in serum triglycerides, HDL cholesterol, total cholesterol, C-Reactive protein, urine microalbumin, liver transaminases, liver fat and the indices of insulin resistance, beta cell secretory capacity, and insulin sensitivity. CONCLUSION: If long-term follow-up proves sustained benefits, such dietary restriction may be an alternative to more drastic options for reversal of type 2 diabetes. This may also help in changing the treatment perspective of a newly detected T2DM from an incurable and inevitably progressive disease to a potentially reversible disease. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5628553/ /pubmed/28989891 http://dx.doi.org/10.4103/ijem.IJEM_206_17 Text en Copyright: © 2017 Indian Journal of Endocrinology and Metabolism http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Brief Communication
Bhatt, Anjali Amit
Choudhari, Priya K.
Mahajan, Rutuja R.
Sayyad, Mehmood G.
Pratyush, Devi D.
Hasan, Imtiaz
Javherani, Rajesh S.
Bothale, Manish M.
Purandare, Vedavati B.
Unnikrishnan, Ambika Gopalakrishnan
Effect of a Low-Calorie Diet on Restoration of Normoglycemia in Obese subjects with Type 2 Diabetes
title Effect of a Low-Calorie Diet on Restoration of Normoglycemia in Obese subjects with Type 2 Diabetes
title_full Effect of a Low-Calorie Diet on Restoration of Normoglycemia in Obese subjects with Type 2 Diabetes
title_fullStr Effect of a Low-Calorie Diet on Restoration of Normoglycemia in Obese subjects with Type 2 Diabetes
title_full_unstemmed Effect of a Low-Calorie Diet on Restoration of Normoglycemia in Obese subjects with Type 2 Diabetes
title_short Effect of a Low-Calorie Diet on Restoration of Normoglycemia in Obese subjects with Type 2 Diabetes
title_sort effect of a low-calorie diet on restoration of normoglycemia in obese subjects with type 2 diabetes
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628553/
https://www.ncbi.nlm.nih.gov/pubmed/28989891
http://dx.doi.org/10.4103/ijem.IJEM_206_17
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