Development of a high quantum yield dye for tumour imaging

A fluorescent dye, FEB, with high fluorescence quantum yield for tumour imaging is reported. FEB dyes can be efficiently synthesized in three steps and then easily modified with either PEG or PEG-iRGD to yield FEB-2000 or FEB-2000-iRGD, respectively. Both modified dyes showed negligible toxicity and...

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Autores principales: Yang, Dan, Wang, Huasen, Sun, Chengjie, Zhao, Hui, Hu, Kuan, Qin, Weirong, Ma, Rui, Yin, Feng, Qin, Xuan, Zhang, Qianling, Liang, Yongye, Li, Zigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628574/
https://www.ncbi.nlm.nih.gov/pubmed/28989666
http://dx.doi.org/10.1039/c7sc02698f
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author Yang, Dan
Wang, Huasen
Sun, Chengjie
Zhao, Hui
Hu, Kuan
Qin, Weirong
Ma, Rui
Yin, Feng
Qin, Xuan
Zhang, Qianling
Liang, Yongye
Li, Zigang
author_facet Yang, Dan
Wang, Huasen
Sun, Chengjie
Zhao, Hui
Hu, Kuan
Qin, Weirong
Ma, Rui
Yin, Feng
Qin, Xuan
Zhang, Qianling
Liang, Yongye
Li, Zigang
author_sort Yang, Dan
collection PubMed
description A fluorescent dye, FEB, with high fluorescence quantum yield for tumour imaging is reported. FEB dyes can be efficiently synthesized in three steps and then easily modified with either PEG or PEG-iRGD to yield FEB-2000 or FEB-2000-iRGD, respectively. Both modified dyes showed negligible toxicity and were thus able to be adopted for in vivo tumour imaging. PEG modification endowed the dye FEB-2000 with both long circulating times and good tumour targeting properties in a MDA-MB-231 xenograft model. Further conjugation with iRGD to generate FEB-2000-iRGD showed minimal targeting enhancement. These results provide a template for the efficient preparation of FEB dyes for use in tumour imaging, thus providing a foundation for future modifications.
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spelling pubmed-56285742017-10-06 Development of a high quantum yield dye for tumour imaging Yang, Dan Wang, Huasen Sun, Chengjie Zhao, Hui Hu, Kuan Qin, Weirong Ma, Rui Yin, Feng Qin, Xuan Zhang, Qianling Liang, Yongye Li, Zigang Chem Sci Chemistry A fluorescent dye, FEB, with high fluorescence quantum yield for tumour imaging is reported. FEB dyes can be efficiently synthesized in three steps and then easily modified with either PEG or PEG-iRGD to yield FEB-2000 or FEB-2000-iRGD, respectively. Both modified dyes showed negligible toxicity and were thus able to be adopted for in vivo tumour imaging. PEG modification endowed the dye FEB-2000 with both long circulating times and good tumour targeting properties in a MDA-MB-231 xenograft model. Further conjugation with iRGD to generate FEB-2000-iRGD showed minimal targeting enhancement. These results provide a template for the efficient preparation of FEB dyes for use in tumour imaging, thus providing a foundation for future modifications. Royal Society of Chemistry 2017-09-01 2017-07-19 /pmc/articles/PMC5628574/ /pubmed/28989666 http://dx.doi.org/10.1039/c7sc02698f Text en This journal is © The Royal Society of Chemistry 2017 http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Yang, Dan
Wang, Huasen
Sun, Chengjie
Zhao, Hui
Hu, Kuan
Qin, Weirong
Ma, Rui
Yin, Feng
Qin, Xuan
Zhang, Qianling
Liang, Yongye
Li, Zigang
Development of a high quantum yield dye for tumour imaging
title Development of a high quantum yield dye for tumour imaging
title_full Development of a high quantum yield dye for tumour imaging
title_fullStr Development of a high quantum yield dye for tumour imaging
title_full_unstemmed Development of a high quantum yield dye for tumour imaging
title_short Development of a high quantum yield dye for tumour imaging
title_sort development of a high quantum yield dye for tumour imaging
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628574/
https://www.ncbi.nlm.nih.gov/pubmed/28989666
http://dx.doi.org/10.1039/c7sc02698f
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