The m(6)A methylation perturbs the Hoogsteen pairing-guided incorporation of an oxidized nucleotide

Natural nucleic acid bases can form Watson–Crick (WC) or Hoogsteen (HG) base pairs. Importantly, 8-oxo-2′-deoxyguanosine (8-oxo-dG) in DNA or 8-oxo-dG 5′-triphosphate (8-oxo-dGTP) favors a syn conformation because of the steric repulsion between O8 and O4′ of the deoxyribose ring. 8-oxo-dGTP can be...

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Detalles Bibliográficos
Autores principales: Wang, Shaoru, Song, Yanyan, Wang, Yafen, Li, Xin, Fu, Boshi, Liu, Yinong, Wang, Jiaqi, Wei, Lai, Tian, Tian, Zhou, Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628602/
https://www.ncbi.nlm.nih.gov/pubmed/29308175
http://dx.doi.org/10.1039/c7sc02340e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628602/
https://www.ncbi.nlm.nih.gov/pubmed/29308175
http://dx.doi.org/10.1039/c7sc02340e

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