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Collateral damage during antibiotic treatment of C. difficile infection in the aged host: Insights into why recurrent disease happens

Clostridium difficile infection (CDI) is one of the most common causes of healthcare-associated infections but an even bigger problem for the aging population. Advanced age leads to higher incidence, higher mortality, and higher recurrences. In our study, recently published in the Journal of Infecti...

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Autores principales: Shin, Jae Hyun, Warren, Cirle A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628656/
https://www.ncbi.nlm.nih.gov/pubmed/28453386
http://dx.doi.org/10.1080/19490976.2017.1323616
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author Shin, Jae Hyun
Warren, Cirle A.
author_facet Shin, Jae Hyun
Warren, Cirle A.
author_sort Shin, Jae Hyun
collection PubMed
description Clostridium difficile infection (CDI) is one of the most common causes of healthcare-associated infections but an even bigger problem for the aging population. Advanced age leads to higher incidence, higher mortality, and higher recurrences. In our study, recently published in the Journal of Infectious Diseases, we investigated the effect of aging on CDI using a mouse model. We were able to demonstrate that aging leads to worse clinical outcomes, as well as lead to changes in microbiota composition and lower antibody production against C. difficile toxin A, but not toxin B. An association between advanced age and lower antibody production against C. difficile is a new finding which would explain the effect of aging on CDI outcome. Vancomycin, an anti-C. difficile antibiotic, led to similar changes in antibody response, suggesting a connection between microbiome and antibody response in the context of aging, which would require a much more nuanced look at the treatment of CDI.
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spelling pubmed-56286562017-10-12 Collateral damage during antibiotic treatment of C. difficile infection in the aged host: Insights into why recurrent disease happens Shin, Jae Hyun Warren, Cirle A. Gut Microbes Addendum Clostridium difficile infection (CDI) is one of the most common causes of healthcare-associated infections but an even bigger problem for the aging population. Advanced age leads to higher incidence, higher mortality, and higher recurrences. In our study, recently published in the Journal of Infectious Diseases, we investigated the effect of aging on CDI using a mouse model. We were able to demonstrate that aging leads to worse clinical outcomes, as well as lead to changes in microbiota composition and lower antibody production against C. difficile toxin A, but not toxin B. An association between advanced age and lower antibody production against C. difficile is a new finding which would explain the effect of aging on CDI outcome. Vancomycin, an anti-C. difficile antibiotic, led to similar changes in antibody response, suggesting a connection between microbiome and antibody response in the context of aging, which would require a much more nuanced look at the treatment of CDI. Taylor & Francis 2017-04-28 /pmc/articles/PMC5628656/ /pubmed/28453386 http://dx.doi.org/10.1080/19490976.2017.1323616 Text en © 2017 The Author(s). Published with license by Taylor & Francis http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Addendum
Shin, Jae Hyun
Warren, Cirle A.
Collateral damage during antibiotic treatment of C. difficile infection in the aged host: Insights into why recurrent disease happens
title Collateral damage during antibiotic treatment of C. difficile infection in the aged host: Insights into why recurrent disease happens
title_full Collateral damage during antibiotic treatment of C. difficile infection in the aged host: Insights into why recurrent disease happens
title_fullStr Collateral damage during antibiotic treatment of C. difficile infection in the aged host: Insights into why recurrent disease happens
title_full_unstemmed Collateral damage during antibiotic treatment of C. difficile infection in the aged host: Insights into why recurrent disease happens
title_short Collateral damage during antibiotic treatment of C. difficile infection in the aged host: Insights into why recurrent disease happens
title_sort collateral damage during antibiotic treatment of c. difficile infection in the aged host: insights into why recurrent disease happens
topic Addendum
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628656/
https://www.ncbi.nlm.nih.gov/pubmed/28453386
http://dx.doi.org/10.1080/19490976.2017.1323616
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