Eluxadoline in the treatment of diarrhea-predominant irritable bowel syndrome

Eluxadoline is a novel drug approved for the management of diarrhea predominant irritable bowel syndrome (IBS-D). It has unique pharmacology and works on three different opioid receptors. Several Phase II and III clinical trials have demonstrated eluxadoline’s efficacy in reducing symptoms related t...

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Detalles Bibliográficos
Autores principales: Özdener, Ayşe Elif, Rivkin, Anastasia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628681/
https://www.ncbi.nlm.nih.gov/pubmed/29033544
http://dx.doi.org/10.2147/DDDT.S127405
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author Özdener, Ayşe Elif
Rivkin, Anastasia
author_facet Özdener, Ayşe Elif
Rivkin, Anastasia
author_sort Özdener, Ayşe Elif
collection PubMed
description Eluxadoline is a novel drug approved for the management of diarrhea predominant irritable bowel syndrome (IBS-D). It has unique pharmacology and works on three different opioid receptors. Several Phase II and III clinical trials have demonstrated eluxadoline’s efficacy in reducing symptoms related to IBS-D. Clinical trial results and postmarketing reports show a risk of pancreatitis in patients without a gallbladder or those abusing alcohol. This review article will include information on clinical trial results related to IBS-D management as well as eluxadoline’s limitations.
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spelling pubmed-56286812017-10-13 Eluxadoline in the treatment of diarrhea-predominant irritable bowel syndrome Özdener, Ayşe Elif Rivkin, Anastasia Drug Des Devel Ther Review Eluxadoline is a novel drug approved for the management of diarrhea predominant irritable bowel syndrome (IBS-D). It has unique pharmacology and works on three different opioid receptors. Several Phase II and III clinical trials have demonstrated eluxadoline’s efficacy in reducing symptoms related to IBS-D. Clinical trial results and postmarketing reports show a risk of pancreatitis in patients without a gallbladder or those abusing alcohol. This review article will include information on clinical trial results related to IBS-D management as well as eluxadoline’s limitations. Dove Medical Press 2017-09-26 /pmc/articles/PMC5628681/ /pubmed/29033544 http://dx.doi.org/10.2147/DDDT.S127405 Text en © 2017 Özdener and Rivkin. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Özdener, Ayşe Elif
Rivkin, Anastasia
Eluxadoline in the treatment of diarrhea-predominant irritable bowel syndrome
title Eluxadoline in the treatment of diarrhea-predominant irritable bowel syndrome
title_full Eluxadoline in the treatment of diarrhea-predominant irritable bowel syndrome
title_fullStr Eluxadoline in the treatment of diarrhea-predominant irritable bowel syndrome
title_full_unstemmed Eluxadoline in the treatment of diarrhea-predominant irritable bowel syndrome
title_short Eluxadoline in the treatment of diarrhea-predominant irritable bowel syndrome
title_sort eluxadoline in the treatment of diarrhea-predominant irritable bowel syndrome
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628681/
https://www.ncbi.nlm.nih.gov/pubmed/29033544
http://dx.doi.org/10.2147/DDDT.S127405
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