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Predictors of HPV incidence and clearance in a cohort of Brazilian HIV-infected women

Persistent infection with high-risk human papillomavirus (HR-HPV) is necessary for the development of precursor lesions and cervical cancer. HPV infection among women living with HIV/AIDS (WLHA) occurs more frequently, presents a higher rate of persistent infections and an earlier progression to can...

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Autores principales: Travassos, Ana Gabriela, Netto, Eduardo, Xavier-Souza, Eveline, Nóbrega, Isabella, Adami, Karina, Timbó, Maiara, Abbehusen, Karen, Fernandes, Sheyla, Duran, Camila, Haguihara, Tatiana, Ferreira, Fábio, Brites, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628817/
https://www.ncbi.nlm.nih.gov/pubmed/28981551
http://dx.doi.org/10.1371/journal.pone.0185423
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author Travassos, Ana Gabriela
Netto, Eduardo
Xavier-Souza, Eveline
Nóbrega, Isabella
Adami, Karina
Timbó, Maiara
Abbehusen, Karen
Fernandes, Sheyla
Duran, Camila
Haguihara, Tatiana
Ferreira, Fábio
Brites, Carlos
author_facet Travassos, Ana Gabriela
Netto, Eduardo
Xavier-Souza, Eveline
Nóbrega, Isabella
Adami, Karina
Timbó, Maiara
Abbehusen, Karen
Fernandes, Sheyla
Duran, Camila
Haguihara, Tatiana
Ferreira, Fábio
Brites, Carlos
author_sort Travassos, Ana Gabriela
collection PubMed
description Persistent infection with high-risk human papillomavirus (HR-HPV) is necessary for the development of precursor lesions and cervical cancer. HPV infection among women living with HIV/AIDS (WLHA) occurs more frequently, presents a higher rate of persistent infections and an earlier progression to cancer. We aimed to evaluate HR-HPV prevalence, incidence and clearance, and its association with HIV viral suppression, immunological response and other risk factors among WLHA followed at an STD/HIV reference center. This was a cohort study conducted at a reference center for STD/AIDS in Northeastern Brazil from September 2013 to September 2015. Follow-up visits were conducted at 6 and 12 months after enrolment, where socio-epidemiological data were obtained. Cervical samples were collected for conventional cytology and HPV DNA research (PCR COBAS® Roche) in addition to blood samples for CD4+ T lymphocyte count and HIV viral load. We prospectively evaluated 333 women. HR-HPV DNA prevalence was 33.3% at baseline. HPV-16 was present in 5.1%, HPV-18 in 3.9% and 29.4% WLHA had other HR-HPV (31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66 and 68). The HR-HPV incidence during the follow-up was 10.8%, at the 6-month visit was 7.7% and at the 12-month visit was 3.7%. Variables associated with HR-HPV incidence were: nulliparity, combined oral contraceptive use and detectable HIV viral load. The HR-HPV clearance rate was 41.7% and was associated with age >30 years and lymphocyte T CD4 count >500 cells/mm3 at enrolment. These findings contribute to the knowledge about a group of women that need more careful HPV screening and describe the association between an efficient immunological response and HIV viral suppression with lower incidence and increased clearance of HR-HPV.
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spelling pubmed-56288172017-10-20 Predictors of HPV incidence and clearance in a cohort of Brazilian HIV-infected women Travassos, Ana Gabriela Netto, Eduardo Xavier-Souza, Eveline Nóbrega, Isabella Adami, Karina Timbó, Maiara Abbehusen, Karen Fernandes, Sheyla Duran, Camila Haguihara, Tatiana Ferreira, Fábio Brites, Carlos PLoS One Research Article Persistent infection with high-risk human papillomavirus (HR-HPV) is necessary for the development of precursor lesions and cervical cancer. HPV infection among women living with HIV/AIDS (WLHA) occurs more frequently, presents a higher rate of persistent infections and an earlier progression to cancer. We aimed to evaluate HR-HPV prevalence, incidence and clearance, and its association with HIV viral suppression, immunological response and other risk factors among WLHA followed at an STD/HIV reference center. This was a cohort study conducted at a reference center for STD/AIDS in Northeastern Brazil from September 2013 to September 2015. Follow-up visits were conducted at 6 and 12 months after enrolment, where socio-epidemiological data were obtained. Cervical samples were collected for conventional cytology and HPV DNA research (PCR COBAS® Roche) in addition to blood samples for CD4+ T lymphocyte count and HIV viral load. We prospectively evaluated 333 women. HR-HPV DNA prevalence was 33.3% at baseline. HPV-16 was present in 5.1%, HPV-18 in 3.9% and 29.4% WLHA had other HR-HPV (31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66 and 68). The HR-HPV incidence during the follow-up was 10.8%, at the 6-month visit was 7.7% and at the 12-month visit was 3.7%. Variables associated with HR-HPV incidence were: nulliparity, combined oral contraceptive use and detectable HIV viral load. The HR-HPV clearance rate was 41.7% and was associated with age >30 years and lymphocyte T CD4 count >500 cells/mm3 at enrolment. These findings contribute to the knowledge about a group of women that need more careful HPV screening and describe the association between an efficient immunological response and HIV viral suppression with lower incidence and increased clearance of HR-HPV. Public Library of Science 2017-10-05 /pmc/articles/PMC5628817/ /pubmed/28981551 http://dx.doi.org/10.1371/journal.pone.0185423 Text en © 2017 Travassos et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Travassos, Ana Gabriela
Netto, Eduardo
Xavier-Souza, Eveline
Nóbrega, Isabella
Adami, Karina
Timbó, Maiara
Abbehusen, Karen
Fernandes, Sheyla
Duran, Camila
Haguihara, Tatiana
Ferreira, Fábio
Brites, Carlos
Predictors of HPV incidence and clearance in a cohort of Brazilian HIV-infected women
title Predictors of HPV incidence and clearance in a cohort of Brazilian HIV-infected women
title_full Predictors of HPV incidence and clearance in a cohort of Brazilian HIV-infected women
title_fullStr Predictors of HPV incidence and clearance in a cohort of Brazilian HIV-infected women
title_full_unstemmed Predictors of HPV incidence and clearance in a cohort of Brazilian HIV-infected women
title_short Predictors of HPV incidence and clearance in a cohort of Brazilian HIV-infected women
title_sort predictors of hpv incidence and clearance in a cohort of brazilian hiv-infected women
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628817/
https://www.ncbi.nlm.nih.gov/pubmed/28981551
http://dx.doi.org/10.1371/journal.pone.0185423
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