Cargando…

Augmentation of VAMP-catalytic activity of botulinum neurotoxin serotype B does not result in increased potency in physiological systems

Botulinum neurotoxins (BoNTs) are used extensively as therapeutic agents. Serotypes A and B are available as marketed products. Higher doses of BoNT/B are required to reach an efficacy similar to that of products containing BoNT/A. Advances in our understanding of BoNT/B mechanism of action have aff...

Descripción completa

Detalles Bibliográficos
Autores principales:	Elliott, Mark, Maignel, Jacquie, Liu, Sai Man, Favre-Guilmard, Christine, Mir, Imran, Farrow, Paul, Hornby, Fraser, Marlin, Sandra, Palan, Shilpa, Beard, Matthew, Krupp, Johannes
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628846/ https://www.ncbi.nlm.nih.gov/pubmed/28982136 http://dx.doi.org/10.1371/journal.pone.0185628

Ejemplares similares

Botulinum Neurotoxins Serotypes A and B induce paralysis of mouse striated and smooth muscles with different potencies
por: Maignel‐Ludop, Jacquie, et al.
Publicado: (2017)

New Modified Recombinant Botulinum Neurotoxin Type F with Enhanced Potency
por: Burgin, David, et al.
Publicado: (2021)

Engineered botulinum neurotoxin B with improved binding to human receptors has enhanced efficacy in preclinical models
por: Elliott, Mark, et al.
Publicado: (2019)

A comparison of biological activity of commercially available purified native botulinum neurotoxin serotypes A1 to F1 in vitro, ex vivo, and in vivo
por: Donald, Sarah, et al.
Publicado: (2018)

Purification and Characterization of Recombinant Botulinum Neurotoxin Serotype FA, Also Known as Serotype H
por: Hackett, Gavin, et al.
Publicado: (2018)

Recombinant botulinum neurotoxin serotype A1 in vivo characterization
por: Périer, Cindy, et al.
Publicado: (2021)

The Expanding Therapeutic Utility of Botulinum Neurotoxins
por: Fonfria, Elena, et al.
Publicado: (2018)

Engineered botulinum neurotoxin B with improved efficacy for targeting human receptors
por: Tao, Liang, et al.
Publicado: (2017)

Optimization of SNAP-25 and VAMP-2 Cleavage by Botulinum Neurotoxin Serotypes A–F Employing Taguchi Design-of-Experiments
por: von Berg, Laura, et al.
Publicado: (2019)

The Isolated Mouse Jejunal Afferent Nerve Assay as a Tool to Assess the Effect of Botulinum Neurotoxins in Visceral Nociception
por: Retailleau, Kevin, et al.
Publicado: (2022)

Emerging Opportunities for Serotypes of Botulinum Neurotoxins
por: Peng Chen, Zhongxing, et al.
Publicado: (2012)

Botulinum Neurotoxin Serotype a Specific Cell-Based Potency Assay to Replace the Mouse Bioassay
por: Fernández-Salas, Ester, et al.
Publicado: (2012)

Monoclonal Antibodies Targeting the Alpha-Exosite of Botulinum Neurotoxin Serotype/A Inhibit Catalytic Activity
por: Fan, Yongfeng, et al.
Publicado: (2015)

BoNT/A in the Urinary Bladder—More to the Story than Silencing of Cholinergic Nerves
por: Ibrahim, Hodan, et al.
Publicado: (2022)

Botulinum Neurotoxin Serotypes Detected by Electrochemical Impedance Spectroscopy
por: Savage, Alison C., et al.
Publicado: (2015)

Development of immunodetection system for botulinum neurotoxin serotype E
por: Sarita, R., et al.
Publicado: (2018)

Detection of VAMP Proteolysis by Tetanus and Botulinum Neurotoxin Type B In Vivo with a Cleavage-Specific Antibody
por: Fabris, Federico, et al.
Publicado: (2022)

A lipid-binding loop of botulinum neurotoxin serotypes B, DC and G is an essential feature to confer their exquisite potency
por: Stern, Daniel, et al.
Publicado: (2018)

Botulinum Neurotoxin F Subtypes Cleaving the VAMP-2 Q(58)–K(59) Peptide Bond Exhibit Unique Catalytic Properties and Substrate Specificities
por: Sikorra, Stefan, et al.
Publicado: (2018)

Monoclonal Antibodies that Inhibit the Proteolytic Activity of Botulinum Neurotoxin Serotype/B
por: Fan, Yongfeng, et al.
Publicado: (2015)

Characterization of Serotype CD Mosaic Botulinum Neurotoxin in Comparison with Serotype C and A
por: Miyashita, Shin-Ichiro, et al.
Publicado: (2023)

A Single Tri-Epitopic Antibody Virtually Recapitulates the Potency of a Combination of Three Monoclonal Antibodies in Neutralization of Botulinum Neurotoxin Serotype A
por: Lou, Jianlong, et al.
Publicado: (2018)

Mechanism of Ganglioside Receptor Recognition by Botulinum Neurotoxin Serotype E
por: Masuyer, Geoffrey, et al.
Publicado: (2021)

Widespread Sequence Variations in VAMP1 across Vertebrates Suggest a Potential Selective Pressure from Botulinum Neurotoxins
por: Peng, Lisheng, et al.
Publicado: (2014)

A human bispecific antibody neutralizes botulinum neurotoxin serotype A
por: Lu, Jiansheng, et al.
Publicado: (2023)

Botulinum Neurotoxin Serotype A Recognizes Its Protein Receptor SV2 by a Different Mechanism than Botulinum Neurotoxin B Synaptotagmin
por: Weisemann, Jasmin, et al.
Publicado: (2016)

Protein Domain Analysis of C. botulinum Type A Neurotoxin and Its Relationship with Other Botulinum Serotypes
por: Sharma, Shashi K., et al.
Publicado: (2009)

Use of Monoclonal Antibodies in the Sensitive Detection and Neutralization of Botulinum Neurotoxin Serotype B
por: Cheng, Luisa W., et al.
Publicado: (2015)

Translocation of botulinum neurotoxin serotype A and associated proteins across the intestinal epithelia
por: Lam, Tina I, et al.
Publicado: (2015)

Probiotic Microorganisms Inhibit Epithelial Cell Internalization of Botulinum Neurotoxin Serotype A
por: Lam, Tina I., et al.
Publicado: (2016)

Fully Human Monoclonal Antibodies Effectively Neutralizing Botulinum Neurotoxin Serotype B
por: Matsumura, Takuhiro, et al.
Publicado: (2020)

Crystal structure of the catalytic domain of botulinum neurotoxin subtype A3
por: Leka, Oneda, et al.
Publicado: (2021)

A three monoclonal antibody combination potently neutralizes multiple botulinum neurotoxin serotype F subtypes
por: Fan, Yongfeng, et al.
Publicado: (2017)

A Three Monoclonal Antibody Combination Potently Neutralizes Multiple Botulinum Neurotoxin Serotype E Subtypes
por: Garcia-Rodriguez, Consuelo, et al.
Publicado: (2018)

On Botulinum Neurotoxin Variability
por: Montecucco, Cesare, et al.
Publicado: (2015)

Content/Potency Assessment of Botulinum Neurotoxin Type-A by Validated Liquid Chromatography Methods and Bioassays
por: Xavier, Bruna, et al.
Publicado: (2019)

Small Molecules Showing Significant Protection of Mice against Botulinum Neurotoxin Serotype A
por: Pang, Yuan-Ping, et al.
Publicado: (2010)

Llama Single Domain Antibodies Specific for the 7 Botulinum Neurotoxin Serotypes as Heptaplex Immunoreagents
por: Conway, Jerry O., et al.
Publicado: (2010)

A Simple, Rapid and Sensitive FRET Assay for Botulinum Neurotoxin Serotype B Detection
por: Guo, Jiubiao, et al.
Publicado: (2014)

Camelid VHH Antibodies that Neutralize Botulinum Neurotoxin Serotype E Intoxication or Protease Function
por: Tremblay, Jacqueline M., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_jconbv7ehk5s36d8jmoeg0339g