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CRISPR-mediated HDAC2 disruption identifies two distinct classes of target genes in human cells
The transcriptional functions of the class I histone deacetylases (HDACs) HDAC1 and HDAC2 are mainly viewed as both repressive and redundant based on murine knockout studies, but they may have additional independent roles and their physiological functions in human cells are not as clearly defined. T...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628847/ https://www.ncbi.nlm.nih.gov/pubmed/28982113 http://dx.doi.org/10.1371/journal.pone.0185627 |