Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data

A variety of models have been proposed to explain regions of recurrent somatic copy number alteration (SCNA) in human cancer. Our study employs Whole Genome DNA Sequence (WGS) data from tumor samples (n = 103) to comprehensively assess the role of the Knudson two hit genetic model in SCNA generation...

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Detalles Bibliográficos
Autores principales: Camacho, Niedzica, Van Loo, Peter, Edwards, Sandra, Kay, Jonathan D., Matthews, Lucy, Haase, Kerstin, Clark, Jeremy, Dennis, Nening, Thomas, Sarah, Kremeyer, Barbara, Zamora, Jorge, Butler, Adam P., Gundem, Gunes, Merson, Sue, Luxton, Hayley, Hawkins, Steve, Ghori, Mohammed, Marsden, Luke, Lambert, Adam, Karaszi, Katalin, Pelvender, Gill, Massie, Charlie E., Kote-Jarai, Zsofia, Raine, Keiran, Jones, David, Howat, William J., Hazell, Steven, Livni, Naomi, Fisher, Cyril, Ogden, Christopher, Kumar, Pardeep, Thompson, Alan, Nicol, David, Mayer, Erik, Dudderidge, Tim, Yu, Yongwei, Zhang, Hongwei, Shah, Nimish C., Gnanapragasam, Vincent J., Isaacs, William, Visakorpi, Tapio, Hamdy, Freddie, Berney, Dan, Verrill, Clare, Warren, Anne Y., Wedge, David C., Lynch, Andrew G., Foster, Christopher S., Lu, Yong Jie, Bova, G. Steven, Whitaker, Hayley C., McDermott, Ultan, Neal, David E., Eeles, Rosalind, Cooper, Colin S., Brewer, Daniel S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628936/
https://www.ncbi.nlm.nih.gov/pubmed/28945760
http://dx.doi.org/10.1371/journal.pgen.1007001

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