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Severe Delayed Gastric Emptying Induces Non-acid Reflux up to Proximal Esophagus in Neurologically Impaired Patients

BACKGROUND/AIMS: The aim of this study is to investigate the degree of delayed gastric emptying (DGE) and evaluate how the severity of DGE affects gastroesophageal reflux disease (GERD) in neurologically impaired (NI) patients utilizing 24-hour multichannel intraluminal impedance pH measurements (pH...

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Autores principales: Ishii, Shinji, Fukahori, Suguru, Asagiri, Kimio, Tanaka, Yoshiaki, Saikusa, Nobuyuki, Hashizume, Naoki, Yoshida, Motomu, Masui, Daisuke, Komatsuzaki, Naoko, Higashidate, Naruki, Sakamoto, Saki, Kurahachi, Tomohiro, Tsuruhisa, Shiori, Nakahara, Hirotomo, Yagi, Minoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Neurogastroenterology and Motility 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628985/
https://www.ncbi.nlm.nih.gov/pubmed/28750491
http://dx.doi.org/10.5056/jnm16211
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author Ishii, Shinji
Fukahori, Suguru
Asagiri, Kimio
Tanaka, Yoshiaki
Saikusa, Nobuyuki
Hashizume, Naoki
Yoshida, Motomu
Masui, Daisuke
Komatsuzaki, Naoko
Higashidate, Naruki
Sakamoto, Saki
Kurahachi, Tomohiro
Tsuruhisa, Shiori
Nakahara, Hirotomo
Yagi, Minoru
author_facet Ishii, Shinji
Fukahori, Suguru
Asagiri, Kimio
Tanaka, Yoshiaki
Saikusa, Nobuyuki
Hashizume, Naoki
Yoshida, Motomu
Masui, Daisuke
Komatsuzaki, Naoko
Higashidate, Naruki
Sakamoto, Saki
Kurahachi, Tomohiro
Tsuruhisa, Shiori
Nakahara, Hirotomo
Yagi, Minoru
author_sort Ishii, Shinji
collection PubMed
description BACKGROUND/AIMS: The aim of this study is to investigate the degree of delayed gastric emptying (DGE) and evaluate how the severity of DGE affects gastroesophageal reflux disease (GERD) in neurologically impaired (NI) patients utilizing 24-hour multichannel intraluminal impedance pH measurements (pH/MII) and (13)C-acetate breath test ((13)C-ABT) analyses. METHODS: (13)C-ABT and pH/MII were conducted in 26 NI patients who were referred to our institution due to suspected GERD. At first, correlation analyses were performed to investigate the correlation between the (13)C-ABT parameters and the clinical or pH/MII parameters. Thereafter, all patients were divided into 2 groups (DGE and severe DGE [SDGE] group) according to each cut off half emptying time (t(1/2), 90–170 minutes). Each pH/MII parameter was compared between the 2 groups in each set-up cutoff t(1/2). RESULTS: The mean t(1/2) of all patients was 215.5 ± 237.2 minutes and the t(1/2) of 24 (92.3%) patients were > 100 minutes. Significant moderate positive correlations were observed between both t(1/2) and lag phase time and the non-acid reflux related parameters. Furthermore, the patients in the SDGE group demonstrated higher non-acid reflux related parameters than those of the DGE groups when the cutoff was t(1/2) ≥ 140 minutes. CONCLUSION: The present study demonstrated that GE with t(1/2) ≥ 140 minutes was related to an increase of non-acid exposure reaching up to the proximal esophagus in NI patients, and indicating that NI patients with SDGE might have a high risk of non-acid GERD.
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spelling pubmed-56289852017-10-17 Severe Delayed Gastric Emptying Induces Non-acid Reflux up to Proximal Esophagus in Neurologically Impaired Patients Ishii, Shinji Fukahori, Suguru Asagiri, Kimio Tanaka, Yoshiaki Saikusa, Nobuyuki Hashizume, Naoki Yoshida, Motomu Masui, Daisuke Komatsuzaki, Naoko Higashidate, Naruki Sakamoto, Saki Kurahachi, Tomohiro Tsuruhisa, Shiori Nakahara, Hirotomo Yagi, Minoru J Neurogastroenterol Motil Original Article BACKGROUND/AIMS: The aim of this study is to investigate the degree of delayed gastric emptying (DGE) and evaluate how the severity of DGE affects gastroesophageal reflux disease (GERD) in neurologically impaired (NI) patients utilizing 24-hour multichannel intraluminal impedance pH measurements (pH/MII) and (13)C-acetate breath test ((13)C-ABT) analyses. METHODS: (13)C-ABT and pH/MII were conducted in 26 NI patients who were referred to our institution due to suspected GERD. At first, correlation analyses were performed to investigate the correlation between the (13)C-ABT parameters and the clinical or pH/MII parameters. Thereafter, all patients were divided into 2 groups (DGE and severe DGE [SDGE] group) according to each cut off half emptying time (t(1/2), 90–170 minutes). Each pH/MII parameter was compared between the 2 groups in each set-up cutoff t(1/2). RESULTS: The mean t(1/2) of all patients was 215.5 ± 237.2 minutes and the t(1/2) of 24 (92.3%) patients were > 100 minutes. Significant moderate positive correlations were observed between both t(1/2) and lag phase time and the non-acid reflux related parameters. Furthermore, the patients in the SDGE group demonstrated higher non-acid reflux related parameters than those of the DGE groups when the cutoff was t(1/2) ≥ 140 minutes. CONCLUSION: The present study demonstrated that GE with t(1/2) ≥ 140 minutes was related to an increase of non-acid exposure reaching up to the proximal esophagus in NI patients, and indicating that NI patients with SDGE might have a high risk of non-acid GERD. Korean Society of Neurogastroenterology and Motility 2017-10 2017-10-30 /pmc/articles/PMC5628985/ /pubmed/28750491 http://dx.doi.org/10.5056/jnm16211 Text en © 2017 The Korean Society of Neurogastroenterology and Motility This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Ishii, Shinji
Fukahori, Suguru
Asagiri, Kimio
Tanaka, Yoshiaki
Saikusa, Nobuyuki
Hashizume, Naoki
Yoshida, Motomu
Masui, Daisuke
Komatsuzaki, Naoko
Higashidate, Naruki
Sakamoto, Saki
Kurahachi, Tomohiro
Tsuruhisa, Shiori
Nakahara, Hirotomo
Yagi, Minoru
Severe Delayed Gastric Emptying Induces Non-acid Reflux up to Proximal Esophagus in Neurologically Impaired Patients
title Severe Delayed Gastric Emptying Induces Non-acid Reflux up to Proximal Esophagus in Neurologically Impaired Patients
title_full Severe Delayed Gastric Emptying Induces Non-acid Reflux up to Proximal Esophagus in Neurologically Impaired Patients
title_fullStr Severe Delayed Gastric Emptying Induces Non-acid Reflux up to Proximal Esophagus in Neurologically Impaired Patients
title_full_unstemmed Severe Delayed Gastric Emptying Induces Non-acid Reflux up to Proximal Esophagus in Neurologically Impaired Patients
title_short Severe Delayed Gastric Emptying Induces Non-acid Reflux up to Proximal Esophagus in Neurologically Impaired Patients
title_sort severe delayed gastric emptying induces non-acid reflux up to proximal esophagus in neurologically impaired patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628985/
https://www.ncbi.nlm.nih.gov/pubmed/28750491
http://dx.doi.org/10.5056/jnm16211
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