Key role of segment IS4 in Cav1.2 inactivation: link between activation and inactivation

Inactivation of L-type calcium channel (Cav1.2) is an important determinant of the length of the cardiac action potential. Here, we report a key role of the voltage-sensing segment IS4 in Cav1.2 inactivation. Neutralization of IS4 charges gradually shifted the steady-state inactivation curve on the...

Descripción completa

Detalles Bibliográficos
Autores principales: Andranovits, Stanislav, Beyl, Stanislav, Hohaus, Annette, Zangerl-Plessl, Eva Maria, Timin, Eugen, Hering, Steffen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Ion channels, Receptors and Transporters
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629230/
https://www.ncbi.nlm.nih.gov/pubmed/28766141
http://dx.doi.org/10.1007/s00424-017-2038-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629230/
https://www.ncbi.nlm.nih.gov/pubmed/28766141
http://dx.doi.org/10.1007/s00424-017-2038-3

Ejemplares similares