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Key role of segment IS4 in Cav1.2 inactivation: link between activation and inactivation

Inactivation of L-type calcium channel (Cav1.2) is an important determinant of the length of the cardiac action potential. Here, we report a key role of the voltage-sensing segment IS4 in Cav1.2 inactivation. Neutralization of IS4 charges gradually shifted the steady-state inactivation curve on the...

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Detalles Bibliográficos
Autores principales:	Andranovits, Stanislav, Beyl, Stanislav, Hohaus, Annette, Zangerl-Plessl, Eva Maria, Timin, Eugen, Hering, Steffen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2017
Materias:	Ion channels, Receptors and Transporters
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629230/ https://www.ncbi.nlm.nih.gov/pubmed/28766141 http://dx.doi.org/10.1007/s00424-017-2038-3

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