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Increased Levels of VEGF-A and HIF-1α in Turkish Children with Crimean-Congo Hemorrhagic Fever

BACKGROUND: Crimean-Congo Hemorrhagic Fever (CCHF) is a disease characterized by serious course, including acute viral fever, ecchymosis, thrombocytopenia, liver dysfunction and high rate of mortality. Hypoxia Inducible Factor-1α (HIF-1α) and Vascular Endothelial Growth Factor-A (VEGF-A) play an imp...

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Autores principales: Sefikogullari, Murat, Kaya, Ali, Aydin, Huseyin, Sancakdar, Enver, Celik, Veysel Kenan, Bagci, Gokhan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629302/
https://www.ncbi.nlm.nih.gov/pubmed/29026849
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author Sefikogullari, Murat
Kaya, Ali
Aydin, Huseyin
Sancakdar, Enver
Celik, Veysel Kenan
Bagci, Gokhan
author_facet Sefikogullari, Murat
Kaya, Ali
Aydin, Huseyin
Sancakdar, Enver
Celik, Veysel Kenan
Bagci, Gokhan
author_sort Sefikogullari, Murat
collection PubMed
description BACKGROUND: Crimean-Congo Hemorrhagic Fever (CCHF) is a disease characterized by serious course, including acute viral fever, ecchymosis, thrombocytopenia, liver dysfunction and high rate of mortality. Hypoxia Inducible Factor-1α (HIF-1α) and Vascular Endothelial Growth Factor-A (VEGF-A) play an important role both in the inflammatory process and plasma leakage. The aim of this study was to define HIF-1α and VEGF-A serum levels obtained from CCHF patients and control group and to investigate whether these factors were correlated with the pathogenesis of this disease. METHODS: Thirty cases younger than 17yr confirmed by RT-PCR and/or ELISA for CCHF were included in this study. Thirty age and sex matched healthy peoples were enrolled as controls. Blood samples collected from the patient and control groups. Serum levels of HIF-1α and VEGF-A were measured with ELISA. RESULTS: Levels of HIF-1α and VEGF-A were statistically significantly increased in CCHF patients compared to the control group (P< 0.05). A significant positive correlation was found between the levels of HIF-1α and VEGF-A in the patient group (P< 0.01). The levels of ALT, AST, CK, aPTT, WBC and Thrombocyte count were significantly higher in the patients than in the control group (P< 0.001). A positive correlation was found among the levels of AST and CK from biochemical parameters and VEGF and HIF-1α in the patient group (P< 0.05) CONCLUSION: HIF-1α and VEGF-A might play an important role in CCHF pathogenesis.
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spelling pubmed-56293022017-10-12 Increased Levels of VEGF-A and HIF-1α in Turkish Children with Crimean-Congo Hemorrhagic Fever Sefikogullari, Murat Kaya, Ali Aydin, Huseyin Sancakdar, Enver Celik, Veysel Kenan Bagci, Gokhan J Arthropod Borne Dis Original Article BACKGROUND: Crimean-Congo Hemorrhagic Fever (CCHF) is a disease characterized by serious course, including acute viral fever, ecchymosis, thrombocytopenia, liver dysfunction and high rate of mortality. Hypoxia Inducible Factor-1α (HIF-1α) and Vascular Endothelial Growth Factor-A (VEGF-A) play an important role both in the inflammatory process and plasma leakage. The aim of this study was to define HIF-1α and VEGF-A serum levels obtained from CCHF patients and control group and to investigate whether these factors were correlated with the pathogenesis of this disease. METHODS: Thirty cases younger than 17yr confirmed by RT-PCR and/or ELISA for CCHF were included in this study. Thirty age and sex matched healthy peoples were enrolled as controls. Blood samples collected from the patient and control groups. Serum levels of HIF-1α and VEGF-A were measured with ELISA. RESULTS: Levels of HIF-1α and VEGF-A were statistically significantly increased in CCHF patients compared to the control group (P< 0.05). A significant positive correlation was found between the levels of HIF-1α and VEGF-A in the patient group (P< 0.01). The levels of ALT, AST, CK, aPTT, WBC and Thrombocyte count were significantly higher in the patients than in the control group (P< 0.001). A positive correlation was found among the levels of AST and CK from biochemical parameters and VEGF and HIF-1α in the patient group (P< 0.05) CONCLUSION: HIF-1α and VEGF-A might play an important role in CCHF pathogenesis. Tehran University of Medical Sciences 2017-03-14 /pmc/articles/PMC5629302/ /pubmed/29026849 Text en Copyright© Iranian Society of Medical Entomology & Tehran University of Medical Sciences http://creativecommons.org/licenses/by/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Original Article
Sefikogullari, Murat
Kaya, Ali
Aydin, Huseyin
Sancakdar, Enver
Celik, Veysel Kenan
Bagci, Gokhan
Increased Levels of VEGF-A and HIF-1α in Turkish Children with Crimean-Congo Hemorrhagic Fever
title Increased Levels of VEGF-A and HIF-1α in Turkish Children with Crimean-Congo Hemorrhagic Fever
title_full Increased Levels of VEGF-A and HIF-1α in Turkish Children with Crimean-Congo Hemorrhagic Fever
title_fullStr Increased Levels of VEGF-A and HIF-1α in Turkish Children with Crimean-Congo Hemorrhagic Fever
title_full_unstemmed Increased Levels of VEGF-A and HIF-1α in Turkish Children with Crimean-Congo Hemorrhagic Fever
title_short Increased Levels of VEGF-A and HIF-1α in Turkish Children with Crimean-Congo Hemorrhagic Fever
title_sort increased levels of vegf-a and hif-1α in turkish children with crimean-congo hemorrhagic fever
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629302/
https://www.ncbi.nlm.nih.gov/pubmed/29026849
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