Influence of the milling parameters on the nucleophilic substitution reaction of activated β-cyclodextrins

The present work focuses on the mechanochemical preparation of industrially important β-cyclodextrin (CD) derivatives. Activated CDs have been reacted with nitrogen and sulfur nucleophiles using a planetary mill equipped with stainless steel, zirconia and glass milling tools of different sizes. It i...

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Detalles Bibliográficos
Autores principales: Jicsinszky, László, Tuza, Kata, Cravotto, Giancarlo, Porcheddu, Andrea, Delogu, Francesco, Colacino, Evelina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2017
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629382/
https://www.ncbi.nlm.nih.gov/pubmed/29062408
http://dx.doi.org/10.3762/bjoc.13.184
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author Jicsinszky, László
Tuza, Kata
Cravotto, Giancarlo
Porcheddu, Andrea
Delogu, Francesco
Colacino, Evelina
author_facet Jicsinszky, László
Tuza, Kata
Cravotto, Giancarlo
Porcheddu, Andrea
Delogu, Francesco
Colacino, Evelina
author_sort Jicsinszky, László
collection PubMed
description The present work focuses on the mechanochemical preparation of industrially important β-cyclodextrin (CD) derivatives. Activated CDs have been reacted with nitrogen and sulfur nucleophiles using a planetary mill equipped with stainless steel, zirconia and glass milling tools of different sizes. It is shown that the milling frequency and the number as well as the size of the milling balls have an effect on the nucleophilic reaction.
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spelling pubmed-56293822017-10-23 Influence of the milling parameters on the nucleophilic substitution reaction of activated β-cyclodextrins Jicsinszky, László Tuza, Kata Cravotto, Giancarlo Porcheddu, Andrea Delogu, Francesco Colacino, Evelina Beilstein J Org Chem Full Research Paper The present work focuses on the mechanochemical preparation of industrially important β-cyclodextrin (CD) derivatives. Activated CDs have been reacted with nitrogen and sulfur nucleophiles using a planetary mill equipped with stainless steel, zirconia and glass milling tools of different sizes. It is shown that the milling frequency and the number as well as the size of the milling balls have an effect on the nucleophilic reaction. Beilstein-Institut 2017-09-07 /pmc/articles/PMC5629382/ /pubmed/29062408 http://dx.doi.org/10.3762/bjoc.13.184 Text en Copyright © 2017, Jicsinszky et al. https://creativecommons.org/licenses/by/4.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Jicsinszky, László
Tuza, Kata
Cravotto, Giancarlo
Porcheddu, Andrea
Delogu, Francesco
Colacino, Evelina
Influence of the milling parameters on the nucleophilic substitution reaction of activated β-cyclodextrins
title Influence of the milling parameters on the nucleophilic substitution reaction of activated β-cyclodextrins
title_full Influence of the milling parameters on the nucleophilic substitution reaction of activated β-cyclodextrins
title_fullStr Influence of the milling parameters on the nucleophilic substitution reaction of activated β-cyclodextrins
title_full_unstemmed Influence of the milling parameters on the nucleophilic substitution reaction of activated β-cyclodextrins
title_short Influence of the milling parameters on the nucleophilic substitution reaction of activated β-cyclodextrins
title_sort influence of the milling parameters on the nucleophilic substitution reaction of activated β-cyclodextrins
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629382/
https://www.ncbi.nlm.nih.gov/pubmed/29062408
http://dx.doi.org/10.3762/bjoc.13.184
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