A multicenter, randomized study of decitabine as epigenetic priming with induction chemotherapy in children with AML

BACKGROUND: Decitabine is a deoxycytidine nucleoside derivative inhibitor of DNA-methyltransferases, which has been studied extensively and is approved for myelodysplastic syndrome in adults but with less focus in children. Accordingly, we conducted a phase 1 multicenter, randomized, open-label stud...

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Detalles Bibliográficos
Autores principales: Gore, Lia, Triche, Timothy J., Farrar, Jason E., Wai, Daniel, Legendre, Christophe, Gooden, Gerald C., Liang, Winnie S., Carpten, John, Lee, David, Alvaro, Frank, Macy, Margaret E., Arndt, Carola, Barnette, Philip, Cooper, Todd, Martin, Laura, Narendran, Aru, Pollard, Jessica, Meshinchi, Soheil, Boklan, Jessica, Arceci, Robert J., Salhia, Bodour
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629751/
https://www.ncbi.nlm.nih.gov/pubmed/29034009
http://dx.doi.org/10.1186/s13148-017-0411-x

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