Adult reference intervals for IgG subclasses with Siemens immunonephelometric assays in Chinese population

OBJECTIVE: To determine the adult reference intervals for the Siemens IgG subclass reagents. METHODS: 636 blood samples of healthy adults were analyzed to determine the level of IgG subclass using the reagents of Siemens immunonephelometric assay with molecular biology kits. RESULTS: IgGSc reference...

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Autores principales: Li, Ping, Liu, Zhongjuan, Wu, Ziyan, Wen, Xiaoting, Li, Liubing, Zhang, Shulan, Xu, Yingchun, Li, Yongzhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629794/
https://www.ncbi.nlm.nih.gov/pubmed/29042863
http://dx.doi.org/10.1186/s13223-017-0216-7
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author Li, Ping
Liu, Zhongjuan
Wu, Ziyan
Wen, Xiaoting
Li, Liubing
Zhang, Shulan
Xu, Yingchun
Li, Yongzhe
author_facet Li, Ping
Liu, Zhongjuan
Wu, Ziyan
Wen, Xiaoting
Li, Liubing
Zhang, Shulan
Xu, Yingchun
Li, Yongzhe
author_sort Li, Ping
collection PubMed
description OBJECTIVE: To determine the adult reference intervals for the Siemens IgG subclass reagents. METHODS: 636 blood samples of healthy adults were analyzed to determine the level of IgG subclass using the reagents of Siemens immunonephelometric assay with molecular biology kits. RESULTS: IgGSc reference intervals were as follows: IgG1 4.45–9.76 g/L, IgG2 2.07–8.57 g/L, IgG3 0.08–0.80 g/L and IgG4 0.05–1.54 g/L. There was an excellent correlation between the total IgG and the sum of the IgG subclasses. No significant gender and age differences were observed. CONCLUSIONS: Our data provide the missing reference intervals and enable the use of the nephelometric IgG subclass reagents in Chinese. The study can offer reference on clinic diagnose.
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spelling pubmed-56297942017-10-17 Adult reference intervals for IgG subclasses with Siemens immunonephelometric assays in Chinese population Li, Ping Liu, Zhongjuan Wu, Ziyan Wen, Xiaoting Li, Liubing Zhang, Shulan Xu, Yingchun Li, Yongzhe Allergy Asthma Clin Immunol Research OBJECTIVE: To determine the adult reference intervals for the Siemens IgG subclass reagents. METHODS: 636 blood samples of healthy adults were analyzed to determine the level of IgG subclass using the reagents of Siemens immunonephelometric assay with molecular biology kits. RESULTS: IgGSc reference intervals were as follows: IgG1 4.45–9.76 g/L, IgG2 2.07–8.57 g/L, IgG3 0.08–0.80 g/L and IgG4 0.05–1.54 g/L. There was an excellent correlation between the total IgG and the sum of the IgG subclasses. No significant gender and age differences were observed. CONCLUSIONS: Our data provide the missing reference intervals and enable the use of the nephelometric IgG subclass reagents in Chinese. The study can offer reference on clinic diagnose. BioMed Central 2017-10-05 /pmc/articles/PMC5629794/ /pubmed/29042863 http://dx.doi.org/10.1186/s13223-017-0216-7 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Li, Ping
Liu, Zhongjuan
Wu, Ziyan
Wen, Xiaoting
Li, Liubing
Zhang, Shulan
Xu, Yingchun
Li, Yongzhe
Adult reference intervals for IgG subclasses with Siemens immunonephelometric assays in Chinese population
title Adult reference intervals for IgG subclasses with Siemens immunonephelometric assays in Chinese population
title_full Adult reference intervals for IgG subclasses with Siemens immunonephelometric assays in Chinese population
title_fullStr Adult reference intervals for IgG subclasses with Siemens immunonephelometric assays in Chinese population
title_full_unstemmed Adult reference intervals for IgG subclasses with Siemens immunonephelometric assays in Chinese population
title_short Adult reference intervals for IgG subclasses with Siemens immunonephelometric assays in Chinese population
title_sort adult reference intervals for igg subclasses with siemens immunonephelometric assays in chinese population
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629794/
https://www.ncbi.nlm.nih.gov/pubmed/29042863
http://dx.doi.org/10.1186/s13223-017-0216-7
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