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Screening antenatal anxiety: Predicting its effect on fetal growth
CONTEXT: Maternal anxiety has an association with low birth weight. However, studies are scarce to determine any association between maternal anxiety and fetal growth. AIMS: This study aims to determine the effect of maternal anxiety on fetal growth, measured by gestational age-dependent increase in...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629877/ https://www.ncbi.nlm.nih.gov/pubmed/29026765 http://dx.doi.org/10.4103/2249-4863.214956 |
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author | Sarkar, Kaushik Das, Goutam Chowdhury, Ranadip Shahbabu, Bhaskar Sarkar, Ishita Maiti, Santu Dasgupta, Aparajita |
author_facet | Sarkar, Kaushik Das, Goutam Chowdhury, Ranadip Shahbabu, Bhaskar Sarkar, Ishita Maiti, Santu Dasgupta, Aparajita |
author_sort | Sarkar, Kaushik |
collection | PubMed |
description | CONTEXT: Maternal anxiety has an association with low birth weight. However, studies are scarce to determine any association between maternal anxiety and fetal growth. AIMS: This study aims to determine the effect of maternal anxiety on fetal growth, measured by gestational age-dependent increase in fetal abdominal circumference (AC). The secondary objective is to determine the effect of maternal anxiety on other fetal parameters (biparietal diameter [BPD], head circumference [HC], femur length [FL]). SETTINGS AND DESIGN: This cross-sectional study was conducted in a tertiary care hospital, Kolkata. MATERIALS AND METHODS: Four hundred and ten pregnant mothers, between 14 and 40 weeks of gestation, were interviewed with socioeconomic and obstetric profile questionnaire and examined for anthropometric profile and presence and severity of pallor. Anxiety was assessed using Generalized Anxiety Disorder-7 (GAD) questionnaire. HC, AC, BPD, and FL were measured by ultrasound biometry. ANALYSIS USED: A multivariable logistic regression analysis was done to determine the predictors of small-for-gestational-age (SGA). A robust mediation analysis was done to determine mediating effect of anxiety on gestational age-dependent increase in fetal AC. RESULTS: Mild (odds ratio [OR](Adjusted) = 6.23, [2.41, 16.15]) and moderate (OR(Adjusted) = 22.42, [5.00, 100.57]) anxiety was significantly associated with SGA fetus. Anxiety increased with the progression of gestation (β(GAD): 0.011 [0.007–0.015]) and it had a negative effect on fetal growth (standardized indirect effect of gestational age-mediated by anxiety on AC: −0.037 [−0.059, −0.022]). Anxiety also attenuated gestational age-dependent increment of HC. CONCLUSION: Mother's anxiety has a gestational age-dependent temporally incremental negative effect on fetal growth and brain development. |
format | Online Article Text |
id | pubmed-5629877 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-56298772017-10-12 Screening antenatal anxiety: Predicting its effect on fetal growth Sarkar, Kaushik Das, Goutam Chowdhury, Ranadip Shahbabu, Bhaskar Sarkar, Ishita Maiti, Santu Dasgupta, Aparajita J Family Med Prim Care Original Article CONTEXT: Maternal anxiety has an association with low birth weight. However, studies are scarce to determine any association between maternal anxiety and fetal growth. AIMS: This study aims to determine the effect of maternal anxiety on fetal growth, measured by gestational age-dependent increase in fetal abdominal circumference (AC). The secondary objective is to determine the effect of maternal anxiety on other fetal parameters (biparietal diameter [BPD], head circumference [HC], femur length [FL]). SETTINGS AND DESIGN: This cross-sectional study was conducted in a tertiary care hospital, Kolkata. MATERIALS AND METHODS: Four hundred and ten pregnant mothers, between 14 and 40 weeks of gestation, were interviewed with socioeconomic and obstetric profile questionnaire and examined for anthropometric profile and presence and severity of pallor. Anxiety was assessed using Generalized Anxiety Disorder-7 (GAD) questionnaire. HC, AC, BPD, and FL were measured by ultrasound biometry. ANALYSIS USED: A multivariable logistic regression analysis was done to determine the predictors of small-for-gestational-age (SGA). A robust mediation analysis was done to determine mediating effect of anxiety on gestational age-dependent increase in fetal AC. RESULTS: Mild (odds ratio [OR](Adjusted) = 6.23, [2.41, 16.15]) and moderate (OR(Adjusted) = 22.42, [5.00, 100.57]) anxiety was significantly associated with SGA fetus. Anxiety increased with the progression of gestation (β(GAD): 0.011 [0.007–0.015]) and it had a negative effect on fetal growth (standardized indirect effect of gestational age-mediated by anxiety on AC: −0.037 [−0.059, −0.022]). Anxiety also attenuated gestational age-dependent increment of HC. CONCLUSION: Mother's anxiety has a gestational age-dependent temporally incremental negative effect on fetal growth and brain development. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5629877/ /pubmed/29026765 http://dx.doi.org/10.4103/2249-4863.214956 Text en Copyright: © 2017 Journal of Family Medicine and Primary Care http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Sarkar, Kaushik Das, Goutam Chowdhury, Ranadip Shahbabu, Bhaskar Sarkar, Ishita Maiti, Santu Dasgupta, Aparajita Screening antenatal anxiety: Predicting its effect on fetal growth |
title | Screening antenatal anxiety: Predicting its effect on fetal growth |
title_full | Screening antenatal anxiety: Predicting its effect on fetal growth |
title_fullStr | Screening antenatal anxiety: Predicting its effect on fetal growth |
title_full_unstemmed | Screening antenatal anxiety: Predicting its effect on fetal growth |
title_short | Screening antenatal anxiety: Predicting its effect on fetal growth |
title_sort | screening antenatal anxiety: predicting its effect on fetal growth |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629877/ https://www.ncbi.nlm.nih.gov/pubmed/29026765 http://dx.doi.org/10.4103/2249-4863.214956 |
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