Rescuing the aberrant sex development of H3K9 demethylase Jmjd1a-deficient mice by modulating H3K9 methylation balance

Histone H3 lysine 9 (H3K9) methylation is a hallmark of heterochromatin. H3K9 demethylation is crucial in mouse sex determination; The H3K9 demethylase Jmjd1a deficiency leads to increased H3K9 methylation at the Sry locus in embryonic gonads, thereby compromising Sry expression and causing male-to-...

Descripción completa

Detalles Bibliográficos
Autores principales: Kuroki, Shunsuke, Okashita, Naoki, Baba, Shoko, Maeda, Ryo, Miyawaki, Shingo, Yano, Masashi, Yamaguchi, Miyoko, Kitano, Satsuki, Miyachi, Hitoshi, Itoh, Akihiro, Yoshida, Minoru, Tachibana, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630185/
https://www.ncbi.nlm.nih.gov/pubmed/28949961
http://dx.doi.org/10.1371/journal.pgen.1007034

Ejemplares similares

Ejemplares similares