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Light reintroduction after dark exposure reactivates plasticity in adults via perisynaptic activation of MMP-9

The sensitivity of ocular dominance to regulation by monocular deprivation is the canonical model of plasticity confined to a critical period. However, we have previously shown that visual deprivation through dark exposure (DE) reactivates critical period plasticity in adults. Previous work assumed...

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Detalles Bibliográficos
Autores principales: Murase, Sachiko, Lantz, Crystal L, Quinlan, Elizabeth M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630258/
https://www.ncbi.nlm.nih.gov/pubmed/28875930
http://dx.doi.org/10.7554/eLife.27345
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author Murase, Sachiko
Lantz, Crystal L
Quinlan, Elizabeth M
author_facet Murase, Sachiko
Lantz, Crystal L
Quinlan, Elizabeth M
author_sort Murase, Sachiko
collection PubMed
description The sensitivity of ocular dominance to regulation by monocular deprivation is the canonical model of plasticity confined to a critical period. However, we have previously shown that visual deprivation through dark exposure (DE) reactivates critical period plasticity in adults. Previous work assumed that the elimination of visual input was sufficient to enhance plasticity in the adult mouse visual cortex. In contrast, here we show that light reintroduction (LRx) after DE is responsible for the reactivation of plasticity. LRx triggers degradation of the ECM, which is blocked by pharmacological inhibition or genetic ablation of matrix metalloproteinase-9 (MMP-9). LRx induces an increase in MMP-9 activity that is perisynaptic and enriched at thalamo-cortical synapses. The reactivation of plasticity by LRx is absent in Mmp9(−/−) mice, and is rescued by hyaluronidase, an enzyme that degrades core ECM components. Thus, the LRx-induced increase in MMP-9 removes constraints on structural and functional plasticity in the mature cortex.
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spelling pubmed-56302582017-10-10 Light reintroduction after dark exposure reactivates plasticity in adults via perisynaptic activation of MMP-9 Murase, Sachiko Lantz, Crystal L Quinlan, Elizabeth M eLife Neuroscience The sensitivity of ocular dominance to regulation by monocular deprivation is the canonical model of plasticity confined to a critical period. However, we have previously shown that visual deprivation through dark exposure (DE) reactivates critical period plasticity in adults. Previous work assumed that the elimination of visual input was sufficient to enhance plasticity in the adult mouse visual cortex. In contrast, here we show that light reintroduction (LRx) after DE is responsible for the reactivation of plasticity. LRx triggers degradation of the ECM, which is blocked by pharmacological inhibition or genetic ablation of matrix metalloproteinase-9 (MMP-9). LRx induces an increase in MMP-9 activity that is perisynaptic and enriched at thalamo-cortical synapses. The reactivation of plasticity by LRx is absent in Mmp9(−/−) mice, and is rescued by hyaluronidase, an enzyme that degrades core ECM components. Thus, the LRx-induced increase in MMP-9 removes constraints on structural and functional plasticity in the mature cortex. eLife Sciences Publications, Ltd 2017-09-06 /pmc/articles/PMC5630258/ /pubmed/28875930 http://dx.doi.org/10.7554/eLife.27345 Text en © 2017, Murase et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Murase, Sachiko
Lantz, Crystal L
Quinlan, Elizabeth M
Light reintroduction after dark exposure reactivates plasticity in adults via perisynaptic activation of MMP-9
title Light reintroduction after dark exposure reactivates plasticity in adults via perisynaptic activation of MMP-9
title_full Light reintroduction after dark exposure reactivates plasticity in adults via perisynaptic activation of MMP-9
title_fullStr Light reintroduction after dark exposure reactivates plasticity in adults via perisynaptic activation of MMP-9
title_full_unstemmed Light reintroduction after dark exposure reactivates plasticity in adults via perisynaptic activation of MMP-9
title_short Light reintroduction after dark exposure reactivates plasticity in adults via perisynaptic activation of MMP-9
title_sort light reintroduction after dark exposure reactivates plasticity in adults via perisynaptic activation of mmp-9
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630258/
https://www.ncbi.nlm.nih.gov/pubmed/28875930
http://dx.doi.org/10.7554/eLife.27345
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