The β-NAD(+) salvage pathway and PKC-mediated signaling influence localized PARP-1 activity and CTCF Poly(ADP)ribosylation

Poly(ADP)ribosylation (PARylation) of the chromatin architectural protein CTCF is critical for CTCF-dependent regulation of chromatin boundary and insulator elements. Loss of CTCF PARylation results in epigenetic silencing of certain tumor suppressor genes through destabilization of nearby chromatin...

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Detalles Bibliográficos
Autores principales: Henderson, David J.P., Miranda, JJ L., Emerson, Beverly M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630287/
https://www.ncbi.nlm.nih.gov/pubmed/29029387
http://dx.doi.org/10.18632/oncotarget.19841

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630287/
https://www.ncbi.nlm.nih.gov/pubmed/29029387
http://dx.doi.org/10.18632/oncotarget.19841

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