Extracellular truncated tau causes early presynaptic dysfunction associated with Alzheimer’s disease and other tauopathies

The largest part of tau secreted from AD nerve terminals and released in cerebral spinal fluid (CSF) is C-terminally truncated, soluble and unaggregated supporting potential extracellular role(s) of NH(2) -derived fragments of protein on synaptic dysfunction underlying neurodegenerative tauopathies,...

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Detalles Bibliográficos
Autores principales: Florenzano, Fulvio, Veronica, Corsetti, Ciasca, Gabriele, Ciotti, Maria Teresa, Pittaluga, Anna, Olivero, Gunedalina, Feligioni, Marco, Iannuzzi, Filomena, Latina, Valentina, Maria Sciacca, Michele Francesco, Sinopoli, Alessandro, Milardi, Danilo, Pappalardo, Giuseppe, Marco, De Spirito, Papi, Massimiliano, Atlante, Anna, Bobba, Antonella, Borreca, Antonella, Calissano, Pietro, Amadoro, Giuseppina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper: Gerotarget (Focus on Aging)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630290/
https://www.ncbi.nlm.nih.gov/pubmed/29029390
http://dx.doi.org/10.18632/oncotarget.17371

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