Intermittent treatment with farnesyltransferase inhibitor and sulforaphane improves cellular homeostasis in Hutchinson-Gilford progeria fibroblasts

Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic condition associated with mutations in the LMNA gene. This disease recapitulates some aspects of normal aging, such as hair loss, thin skin, joint stiffness, and atherosclerosis. The latter leads to heart attack or stroke that causes deat...

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Detalles Bibliográficos
Autores principales: Gabriel, Diana, Shafry, Dinah Dorith, Gordon, Leslie B., Djabali, Karima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper: Gerotarget (Focus on Aging)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630293/
https://www.ncbi.nlm.nih.gov/pubmed/29029393
http://dx.doi.org/10.18632/oncotarget.19363

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