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Oxymatrine suppresses the growth and invasion of MG63 cells by up-regulating PTEN and promoting its nuclear translocation

Studies demonstrated that reduced PTEN levels are associated with poor prognoses of osteosarcoma. The nuclear localization of PTEN is important for its tumor suppressive function. Equally importantly, PTEN is the most significant negative regulator of PI3K/Akt signaling cascade, the constitutively a...

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Detalles Bibliográficos
Autores principales:	He, Ming, Jiang, Linlin, Li, Bin, Wang, Guangbin, Wang, Jiashi, Fu, Yonghui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630315/ https://www.ncbi.nlm.nih.gov/pubmed/29029415 http://dx.doi.org/10.18632/oncotarget.17783

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