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Effects of exercise on capillaries in the white matter of transgenic AD mice

Previous studies have shown that exercise can prevent white matter atrophy in APP/PS1 transgenic Alzheimer’s disease (AD) mice. However, the mechanism of this protective effect remains unknown. To further understand this issue, we investigated the effects of exercise on the blood supply of white mat...

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Autores principales: Zhang, Yi, Chao, Feng-Lei, Zhou, Chun-Ni, Jiang, Lin, Zhang, Lei, Chen, Lin-Mu, Luo, Yan-Min, Xiao, Qian, Tang, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630378/
https://www.ncbi.nlm.nih.gov/pubmed/29029478
http://dx.doi.org/10.18632/oncotarget.19505
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author Zhang, Yi
Chao, Feng-Lei
Zhou, Chun-Ni
Jiang, Lin
Zhang, Lei
Chen, Lin-Mu
Luo, Yan-Min
Xiao, Qian
Tang, Yong
author_facet Zhang, Yi
Chao, Feng-Lei
Zhou, Chun-Ni
Jiang, Lin
Zhang, Lei
Chen, Lin-Mu
Luo, Yan-Min
Xiao, Qian
Tang, Yong
author_sort Zhang, Yi
collection PubMed
description Previous studies have shown that exercise can prevent white matter atrophy in APP/PS1 transgenic Alzheimer’s disease (AD) mice. However, the mechanism of this protective effect remains unknown. To further understand this issue, we investigated the effects of exercise on the blood supply of white matter in transgenic AD mice. Six-month-old male APP/PS1 mice were randomly divided into a control group and a running group, and age-matched non-transgenic littermates were used as a wild-type control group. Mice in the running group ran on a treadmill at low intensity for four months. Then, spatial learning and memory abilities, white matter and white matter capillaries were examined in all mice. The 10-month-old AD mice exhibited deficits in cognitive function, and 4 months of exercise improved these deficits. The white matter volume and the total length, total volume and total surface area of the white matter capillaries were decreased in the 10-month-old AD mice, and 4 months of exercise dramatically delayed the changes in these parameters in the AD mice. Our results demonstrate that even low-intensity running exercise can improve spatial learning and memory abilities, delay white matter atrophy and protect white matter capillaries in early-stage AD mice. Protecting capillaries might be an important structural basis for the exercise-induced protection of the structural integrity of white matter in AD.
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spelling pubmed-56303782017-10-12 Effects of exercise on capillaries in the white matter of transgenic AD mice Zhang, Yi Chao, Feng-Lei Zhou, Chun-Ni Jiang, Lin Zhang, Lei Chen, Lin-Mu Luo, Yan-Min Xiao, Qian Tang, Yong Oncotarget Research Paper Previous studies have shown that exercise can prevent white matter atrophy in APP/PS1 transgenic Alzheimer’s disease (AD) mice. However, the mechanism of this protective effect remains unknown. To further understand this issue, we investigated the effects of exercise on the blood supply of white matter in transgenic AD mice. Six-month-old male APP/PS1 mice were randomly divided into a control group and a running group, and age-matched non-transgenic littermates were used as a wild-type control group. Mice in the running group ran on a treadmill at low intensity for four months. Then, spatial learning and memory abilities, white matter and white matter capillaries were examined in all mice. The 10-month-old AD mice exhibited deficits in cognitive function, and 4 months of exercise improved these deficits. The white matter volume and the total length, total volume and total surface area of the white matter capillaries were decreased in the 10-month-old AD mice, and 4 months of exercise dramatically delayed the changes in these parameters in the AD mice. Our results demonstrate that even low-intensity running exercise can improve spatial learning and memory abilities, delay white matter atrophy and protect white matter capillaries in early-stage AD mice. Protecting capillaries might be an important structural basis for the exercise-induced protection of the structural integrity of white matter in AD. Impact Journals LLC 2017-07-22 /pmc/articles/PMC5630378/ /pubmed/29029478 http://dx.doi.org/10.18632/oncotarget.19505 Text en Copyright: © 2017 Zhang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Zhang, Yi
Chao, Feng-Lei
Zhou, Chun-Ni
Jiang, Lin
Zhang, Lei
Chen, Lin-Mu
Luo, Yan-Min
Xiao, Qian
Tang, Yong
Effects of exercise on capillaries in the white matter of transgenic AD mice
title Effects of exercise on capillaries in the white matter of transgenic AD mice
title_full Effects of exercise on capillaries in the white matter of transgenic AD mice
title_fullStr Effects of exercise on capillaries in the white matter of transgenic AD mice
title_full_unstemmed Effects of exercise on capillaries in the white matter of transgenic AD mice
title_short Effects of exercise on capillaries in the white matter of transgenic AD mice
title_sort effects of exercise on capillaries in the white matter of transgenic ad mice
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630378/
https://www.ncbi.nlm.nih.gov/pubmed/29029478
http://dx.doi.org/10.18632/oncotarget.19505
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