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Clinicopathologic implications of the miR-197/PD-L1 axis in oral squamous cell carcinoma

Immune escape of a tumor from tumor-infiltrating lymphocytes (TILs) is induced by PD-L1, which is suppressed by miR-197. We investigated the clinicopathologic implications of the miR-197/PD-L1 axis and its effects on TILs and the clinicopathologic features of oral squamous cell carcinoma (OSCC). We...

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Autores principales: Ahn, Hyein, Yang, Jeong Mi, Kim, Hyojin, Chung, Jin-Haeng, Ahn, Soon-Hyun, Jeong, Woo-Jin, Paik, Jin Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630402/
https://www.ncbi.nlm.nih.gov/pubmed/29029502
http://dx.doi.org/10.18632/oncotarget.19842
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author Ahn, Hyein
Yang, Jeong Mi
Kim, Hyojin
Chung, Jin-Haeng
Ahn, Soon-Hyun
Jeong, Woo-Jin
Paik, Jin Ho
author_facet Ahn, Hyein
Yang, Jeong Mi
Kim, Hyojin
Chung, Jin-Haeng
Ahn, Soon-Hyun
Jeong, Woo-Jin
Paik, Jin Ho
author_sort Ahn, Hyein
collection PubMed
description Immune escape of a tumor from tumor-infiltrating lymphocytes (TILs) is induced by PD-L1, which is suppressed by miR-197. We investigated the clinicopathologic implications of the miR-197/PD-L1 axis and its effects on TILs and the clinicopathologic features of oral squamous cell carcinoma (OSCC). We used RT-PCR and immunohistochemistry in 68 OSCC patients to analyze the correlations between tumoral expression of miR-197 and PD-L1 and the degree of tumoral invasion by TILs (CD3+, CD4+, CD8+, PD-1+, FoxP3+, and CD20+ lymphocytes). PD-L1 levels correlated inversely with miR-197 but correlated positively with TILs. The aggressive features of OSCC, including high stage, angiolymphatic invasion, perineural invasion, and death, were associated with TIL depletion. High T stage (T4) tumors also had low PD-L1 but had high miR-197 expression. In a univariate survival analysis of the full cohort, high miR-197 was associated with poor overall survival, whereas high PD-L1 expression (2+) associated with good overall survival. In a multivariate analysis stratified based on miR-197 (median), high PD-L1 expression (2+) was an independent favorable prognostic factor for overall survival (P = 0.040) in the miR-197(high) subgroup but not the miR-197(low) subgroup. These findings may have clinicopathologic implications for the miR-197/PD-L1 axis and TILs in OSCC.
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spelling pubmed-56304022017-10-12 Clinicopathologic implications of the miR-197/PD-L1 axis in oral squamous cell carcinoma Ahn, Hyein Yang, Jeong Mi Kim, Hyojin Chung, Jin-Haeng Ahn, Soon-Hyun Jeong, Woo-Jin Paik, Jin Ho Oncotarget Research Paper Immune escape of a tumor from tumor-infiltrating lymphocytes (TILs) is induced by PD-L1, which is suppressed by miR-197. We investigated the clinicopathologic implications of the miR-197/PD-L1 axis and its effects on TILs and the clinicopathologic features of oral squamous cell carcinoma (OSCC). We used RT-PCR and immunohistochemistry in 68 OSCC patients to analyze the correlations between tumoral expression of miR-197 and PD-L1 and the degree of tumoral invasion by TILs (CD3+, CD4+, CD8+, PD-1+, FoxP3+, and CD20+ lymphocytes). PD-L1 levels correlated inversely with miR-197 but correlated positively with TILs. The aggressive features of OSCC, including high stage, angiolymphatic invasion, perineural invasion, and death, were associated with TIL depletion. High T stage (T4) tumors also had low PD-L1 but had high miR-197 expression. In a univariate survival analysis of the full cohort, high miR-197 was associated with poor overall survival, whereas high PD-L1 expression (2+) associated with good overall survival. In a multivariate analysis stratified based on miR-197 (median), high PD-L1 expression (2+) was an independent favorable prognostic factor for overall survival (P = 0.040) in the miR-197(high) subgroup but not the miR-197(low) subgroup. These findings may have clinicopathologic implications for the miR-197/PD-L1 axis and TILs in OSCC. Impact Journals LLC 2017-08-03 /pmc/articles/PMC5630402/ /pubmed/29029502 http://dx.doi.org/10.18632/oncotarget.19842 Text en Copyright: © 2017 Ahn et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Ahn, Hyein
Yang, Jeong Mi
Kim, Hyojin
Chung, Jin-Haeng
Ahn, Soon-Hyun
Jeong, Woo-Jin
Paik, Jin Ho
Clinicopathologic implications of the miR-197/PD-L1 axis in oral squamous cell carcinoma
title Clinicopathologic implications of the miR-197/PD-L1 axis in oral squamous cell carcinoma
title_full Clinicopathologic implications of the miR-197/PD-L1 axis in oral squamous cell carcinoma
title_fullStr Clinicopathologic implications of the miR-197/PD-L1 axis in oral squamous cell carcinoma
title_full_unstemmed Clinicopathologic implications of the miR-197/PD-L1 axis in oral squamous cell carcinoma
title_short Clinicopathologic implications of the miR-197/PD-L1 axis in oral squamous cell carcinoma
title_sort clinicopathologic implications of the mir-197/pd-l1 axis in oral squamous cell carcinoma
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630402/
https://www.ncbi.nlm.nih.gov/pubmed/29029502
http://dx.doi.org/10.18632/oncotarget.19842
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