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Long-Term Follow-Up in a Girl with Cystic Fibrosis and Diabetes Since the First Year of Life

Diabetes mellitus is the most common comorbidity in cystic fibrosis (CF). Recently, more attention has been paid to early glucose metabolism derangements (GMDs). The subject of this report is a female patient, affected by CF since 3 months of age. She presented with intermittent diabetes during earl...

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Autores principales: Fattorusso, Valentina, Casale, Alida, Raia, Valeria, Mozzillo, Enza, Franzese, Adriana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630546/
https://www.ncbi.nlm.nih.gov/pubmed/28770464
http://dx.doi.org/10.1007/s13300-017-0289-9
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author Fattorusso, Valentina
Casale, Alida
Raia, Valeria
Mozzillo, Enza
Franzese, Adriana
author_facet Fattorusso, Valentina
Casale, Alida
Raia, Valeria
Mozzillo, Enza
Franzese, Adriana
author_sort Fattorusso, Valentina
collection PubMed
description Diabetes mellitus is the most common comorbidity in cystic fibrosis (CF). Recently, more attention has been paid to early glucose metabolism derangements (GMDs). The subject of this report is a female patient, affected by CF since 3 months of age. She presented with intermittent diabetes during early childhood. At the age of 10 years, oral glucose tolerance test (OGTT) was performed and showed glucose intolerance (IGT) status; glargine insulin therapy was started. At the age of 13 years, CF-related diabetes with fasting hyperglycemia occurred, so rapid insulin at meals was added. During the following year, clinical and nutritional status improved. Stable clinical conditions were observed in the following 3 years. This is the first case of very long-term follow-up concerning a CF patient with GMDs. Our case confirms the importance of paying attention to early GMDs in very young CF patients and seems to suggest that earlier therapy could ameliorate CF natural history.
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spelling pubmed-56305462017-10-23 Long-Term Follow-Up in a Girl with Cystic Fibrosis and Diabetes Since the First Year of Life Fattorusso, Valentina Casale, Alida Raia, Valeria Mozzillo, Enza Franzese, Adriana Diabetes Ther Case Report Diabetes mellitus is the most common comorbidity in cystic fibrosis (CF). Recently, more attention has been paid to early glucose metabolism derangements (GMDs). The subject of this report is a female patient, affected by CF since 3 months of age. She presented with intermittent diabetes during early childhood. At the age of 10 years, oral glucose tolerance test (OGTT) was performed and showed glucose intolerance (IGT) status; glargine insulin therapy was started. At the age of 13 years, CF-related diabetes with fasting hyperglycemia occurred, so rapid insulin at meals was added. During the following year, clinical and nutritional status improved. Stable clinical conditions were observed in the following 3 years. This is the first case of very long-term follow-up concerning a CF patient with GMDs. Our case confirms the importance of paying attention to early GMDs in very young CF patients and seems to suggest that earlier therapy could ameliorate CF natural history. Springer Healthcare 2017-08-02 2017-10 /pmc/articles/PMC5630546/ /pubmed/28770464 http://dx.doi.org/10.1007/s13300-017-0289-9 Text en © The Author(s) 2017 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Case Report
Fattorusso, Valentina
Casale, Alida
Raia, Valeria
Mozzillo, Enza
Franzese, Adriana
Long-Term Follow-Up in a Girl with Cystic Fibrosis and Diabetes Since the First Year of Life
title Long-Term Follow-Up in a Girl with Cystic Fibrosis and Diabetes Since the First Year of Life
title_full Long-Term Follow-Up in a Girl with Cystic Fibrosis and Diabetes Since the First Year of Life
title_fullStr Long-Term Follow-Up in a Girl with Cystic Fibrosis and Diabetes Since the First Year of Life
title_full_unstemmed Long-Term Follow-Up in a Girl with Cystic Fibrosis and Diabetes Since the First Year of Life
title_short Long-Term Follow-Up in a Girl with Cystic Fibrosis and Diabetes Since the First Year of Life
title_sort long-term follow-up in a girl with cystic fibrosis and diabetes since the first year of life
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630546/
https://www.ncbi.nlm.nih.gov/pubmed/28770464
http://dx.doi.org/10.1007/s13300-017-0289-9
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