The drinking water contaminant dibromoacetonitrile delays G1-S transition and suppresses Chk1 activation at broken replication forks

Chlorination of drinking water protects humans from water-born pathogens, but it also produces low concentrations of dibromoacetonitrile (DBAN), a common disinfectant by-product found in many water supply systems. DBAN is not mutagenic but causes DNA breaks and elevates sister chromatid exchange in...

Descripción completa

Detalles Bibliográficos
Autores principales: Caspari, Thomas, Dyer, James, Fenner, Nathalie, Dunn, Christian, Freeman, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630572/
https://www.ncbi.nlm.nih.gov/pubmed/28986587
http://dx.doi.org/10.1038/s41598-017-13033-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630572/
https://www.ncbi.nlm.nih.gov/pubmed/28986587
http://dx.doi.org/10.1038/s41598-017-13033-8

Ejemplares similares