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The drinking water contaminant dibromoacetonitrile delays G1-S transition and suppresses Chk1 activation at broken replication forks

Chlorination of drinking water protects humans from water-born pathogens, but it also produces low concentrations of dibromoacetonitrile (DBAN), a common disinfectant by-product found in many water supply systems. DBAN is not mutagenic but causes DNA breaks and elevates sister chromatid exchange in...

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Detalles Bibliográficos
Autores principales:	Caspari, Thomas, Dyer, James, Fenner, Nathalie, Dunn, Christian, Freeman, Chris
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630572/ https://www.ncbi.nlm.nih.gov/pubmed/28986587 http://dx.doi.org/10.1038/s41598-017-13033-8

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