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Activation-Induced Conformational Changes of Dopamine D3 Receptor Promote the Formation of the Internal Water Channel
The atomic-level dopamine activation mechanism for transmitting extracellular ligand binding events through transmembrane helices to the cytoplasmic G protein remains unclear. In the present study, the complete dopamine D3 receptor (D3R), with a homology-modeled N-terminus, was constructed to dock d...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630584/ https://www.ncbi.nlm.nih.gov/pubmed/28986565 http://dx.doi.org/10.1038/s41598-017-13155-z |