Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA)

Hepatic mitochondria play a central role in the regulation of intermediary metabolism and maintenance of normoglycemia, and there is great interest in assessing rates of hepatic mitochondrial citrate synthase flux (V(CS)) and pyruvate carboxylase flux (V(PC)) in vivo. Here, we show that a positional...

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Detalles Bibliográficos
Autores principales: Perry, Rachel J., Peng, Liang, Cline, Gary W., Butrico, Gina M., Wang, Yongliang, Zhang, Xian-Man, Rothman, Douglas L., Petersen, Kitt Falk, Shulman, Gerald I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630596/
https://www.ncbi.nlm.nih.gov/pubmed/28986525
http://dx.doi.org/10.1038/s41467-017-01143-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630596/
https://www.ncbi.nlm.nih.gov/pubmed/28986525
http://dx.doi.org/10.1038/s41467-017-01143-w

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