A Novel Mouse Model of iNKT Cell-deficiency Generated by CRISPR/Cas9 Reveals a Pathogenic Role of iNKT Cells in Metabolic Disease

iNKT cells play important roles in immune regulation by bridging the innate and acquired immune systems. The functions of iNKT cells have been investigated in mice lacking the Traj18 gene segment that were generated by traditional embryonic stem cell technology, but these animals contain a biased T...

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Detalles Bibliográficos
Autores principales: Ren, Yue, Sekine-Kondo, Etsuko, Shibata, Risa, Kato-Itoh, Megumi, Umino, Ayumi, Yanagida, Ayaka, Satoh, Masashi, Inoue, Komaki, Yamaguchi, Tomoyuki, Mochida, Keiichi, Nakae, Susumu, Van Kaer, Luc, Iwabuchi, Kazuya, Nakauchi, Hiromitsu, Watarai, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630609/
https://www.ncbi.nlm.nih.gov/pubmed/28986544
http://dx.doi.org/10.1038/s41598-017-12475-4

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