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Galectin-3 captures interferon-gamma in the tumor matrix reducing chemokine gradient production and T-cell tumor infiltration

The presence of T cells in tumors predicts overall survival for cancer patients. However, why most tumors are poorly infiltrated by T cells is barely understood. T-cell recruitment towards the tumor requires a chemokine gradient of the critical IFNγ-induced chemokines CXCL9/10/11. Here, we describe...

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Detalles Bibliográficos
Autores principales:	Gordon-Alonso, Monica, Hirsch, Thibault, Wildmann, Claude, van der Bruggen, Pierre
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630615/ https://www.ncbi.nlm.nih.gov/pubmed/28986561 http://dx.doi.org/10.1038/s41467-017-00925-6

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