Cyclophilin D ablation is associated with increased end-ischemic mitochondrial hexokinase activity

Both the absence of cyclophilin D (CypD) and the presence of mitochondrial bound hexokinase II (mtHKII) protect the heart against ischemia/reperfusion (I/R) injury. It is unknown whether CypD determines the amount of mtHKII in the heart. We examined whether CypD affects mtHK in normoxic, ischemic an...

Descripción completa

Detalles Bibliográficos
Autores principales: Nederlof, Rianne, van den Elshout, Mark A. M., Koeman, Anneke, Uthman, Laween, Koning, Iris, Eerbeek, Otto, Weber, Nina C., Hollmann, Markus W., Zuurbier, Coert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630626/
https://www.ncbi.nlm.nih.gov/pubmed/28986541
http://dx.doi.org/10.1038/s41598-017-13096-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630626/
https://www.ncbi.nlm.nih.gov/pubmed/28986541
http://dx.doi.org/10.1038/s41598-017-13096-7

Ejemplares similares