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Cyclophilin D ablation is associated with increased end-ischemic mitochondrial hexokinase activity

Both the absence of cyclophilin D (CypD) and the presence of mitochondrial bound hexokinase II (mtHKII) protect the heart against ischemia/reperfusion (I/R) injury. It is unknown whether CypD determines the amount of mtHKII in the heart. We examined whether CypD affects mtHK in normoxic, ischemic an...

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Detalles Bibliográficos
Autores principales:	Nederlof, Rianne, van den Elshout, Mark A. M., Koeman, Anneke, Uthman, Laween, Koning, Iris, Eerbeek, Otto, Weber, Nina C., Hollmann, Markus W., Zuurbier, Coert J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630626/ https://www.ncbi.nlm.nih.gov/pubmed/28986541 http://dx.doi.org/10.1038/s41598-017-13096-7

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