Low incidence of the immune reconstitution inflammatory syndrome among HIV-infected patients starting antiretroviral therapy in Gabon: a prospective cohort study

There is a paucity of data on the immune reconstitution inflammatory syndrome (IRIS) in the Central African region. We followed ART-naive HIV-infected patients initiating antiretroviral therapy in an HIV clinic in Gabon, for 6 months. Among 101 patients, IRIS was diagnosed in five. All IRIS cases we...

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Detalles Bibliográficos
Autores principales: Janssen, S., Osbak, K., Holman, R., Hermans, S., Moekotte, A., Knap, M., Rossatanga, E., Massinga-Loembe, M., Alabi, A., Adegnika, A., Meenken, C., van Vugt, M., Kremsner, P. G., Meintjes, G., van der Poll, T., Grobusch, M. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630650/
https://www.ncbi.nlm.nih.gov/pubmed/28349491
http://dx.doi.org/10.1007/s15010-017-1000-9
Descripción
Sumario:There is a paucity of data on the immune reconstitution inflammatory syndrome (IRIS) in the Central African region. We followed ART-naive HIV-infected patients initiating antiretroviral therapy in an HIV clinic in Gabon, for 6 months. Among 101 patients, IRIS was diagnosed in five. All IRIS cases were mucocutaneous manifestations. There were no cases of tuberculosis (TB) IRIS, but active TB (n = 20) was associated with developing other forms of IRIS (p = 0.02). Six patients died. The incidence of IRIS is low in Gabon, with mild, mucocutaneous manifestations. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s15010-017-1000-9) contains supplementary material, which is available to authorized users.

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