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The Epidemiology of Non-tuberculous Mycobacteria (NTM) from Non-pulmonary Sites over 4 Years in Nebraska

BACKGROUND: The recent outbreak of M. chimaera has focused attention on NTM species as the potential source of other clusters of infection. Since 2010 NTMs have been reportable in Nebraska. METHODS: The NEDSS data base for Nebraska was searched for all NTM infections reported from May 1, 2013 throug...

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Autores principales: Tierney, Maureen, Pedati, Caitlin, Keyser, Alison, Safranek, Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630832/
http://dx.doi.org/10.1093/ofid/ofx163.1792
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author Tierney, Maureen
Pedati, Caitlin
Keyser, Alison
Safranek, Tom
author_facet Tierney, Maureen
Pedati, Caitlin
Keyser, Alison
Safranek, Tom
author_sort Tierney, Maureen
collection PubMed
description BACKGROUND: The recent outbreak of M. chimaera has focused attention on NTM species as the potential source of other clusters of infection. Since 2010 NTMs have been reportable in Nebraska. METHODS: The NEDSS data base for Nebraska was searched for all NTM infections reported from May 1, 2013 through April 30, 2017. These entries were reviewed for species or group type and source of material. All pulmonary isolates were excluded. RESULTS: Over 4 years, 421 lab reports of NTMs from non-pulmonary sites were received by the DPH. The most common group isolated was M. avium intracellulare group consisting of 246 specimens. Next was M. chelonae with 57 specimens, followed by M. fortuitum with 32, and M. abscessus and M. gordonae with 17 each. Three or fewer isolates of M. kansasii, M. marinum, M. mucogenicum or M. arupense were reported. Eight isolates were not speciated. The sources of those isolates were included in the report 46% of the time. CONCLUSION: The majority of NTM reported in Nebraska over 4 years came from an abscess, wound, mass, bone, joint or skin source. Interesting results included: the number of cases detected by blood culture (between 15 and 20%) in non-MAI NTMS, the number of abdominal sources or stool (5–10% each) in non-MAI NTM, and the unusual sites discovered such as the CSF (MAI only), peritoneal fluid, ear, eye, and cervix. These results suggest that looking for NTM in the blood or stool could be an effective way of making the diagnosis, that it is important to consider NTM in abdominal infections and infections of peritoneal dialysis fluid of unclear etiology. Lastly, NTM may play a role in infections in unusual sites such as the eye, the ear or cervix. DISCLOSURES: All authors: No reported disclosures.
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spelling pubmed-56308322017-11-07 The Epidemiology of Non-tuberculous Mycobacteria (NTM) from Non-pulmonary Sites over 4 Years in Nebraska Tierney, Maureen Pedati, Caitlin Keyser, Alison Safranek, Tom Open Forum Infect Dis Abstracts BACKGROUND: The recent outbreak of M. chimaera has focused attention on NTM species as the potential source of other clusters of infection. Since 2010 NTMs have been reportable in Nebraska. METHODS: The NEDSS data base for Nebraska was searched for all NTM infections reported from May 1, 2013 through April 30, 2017. These entries were reviewed for species or group type and source of material. All pulmonary isolates were excluded. RESULTS: Over 4 years, 421 lab reports of NTMs from non-pulmonary sites were received by the DPH. The most common group isolated was M. avium intracellulare group consisting of 246 specimens. Next was M. chelonae with 57 specimens, followed by M. fortuitum with 32, and M. abscessus and M. gordonae with 17 each. Three or fewer isolates of M. kansasii, M. marinum, M. mucogenicum or M. arupense were reported. Eight isolates were not speciated. The sources of those isolates were included in the report 46% of the time. CONCLUSION: The majority of NTM reported in Nebraska over 4 years came from an abscess, wound, mass, bone, joint or skin source. Interesting results included: the number of cases detected by blood culture (between 15 and 20%) in non-MAI NTMS, the number of abdominal sources or stool (5–10% each) in non-MAI NTM, and the unusual sites discovered such as the CSF (MAI only), peritoneal fluid, ear, eye, and cervix. These results suggest that looking for NTM in the blood or stool could be an effective way of making the diagnosis, that it is important to consider NTM in abdominal infections and infections of peritoneal dialysis fluid of unclear etiology. Lastly, NTM may play a role in infections in unusual sites such as the eye, the ear or cervix. DISCLOSURES: All authors: No reported disclosures. Oxford University Press 2017-10-04 /pmc/articles/PMC5630832/ http://dx.doi.org/10.1093/ofid/ofx163.1792 Text en © The Author 2017. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Abstracts
Tierney, Maureen
Pedati, Caitlin
Keyser, Alison
Safranek, Tom
The Epidemiology of Non-tuberculous Mycobacteria (NTM) from Non-pulmonary Sites over 4 Years in Nebraska
title The Epidemiology of Non-tuberculous Mycobacteria (NTM) from Non-pulmonary Sites over 4 Years in Nebraska
title_full The Epidemiology of Non-tuberculous Mycobacteria (NTM) from Non-pulmonary Sites over 4 Years in Nebraska
title_fullStr The Epidemiology of Non-tuberculous Mycobacteria (NTM) from Non-pulmonary Sites over 4 Years in Nebraska
title_full_unstemmed The Epidemiology of Non-tuberculous Mycobacteria (NTM) from Non-pulmonary Sites over 4 Years in Nebraska
title_short The Epidemiology of Non-tuberculous Mycobacteria (NTM) from Non-pulmonary Sites over 4 Years in Nebraska
title_sort epidemiology of non-tuberculous mycobacteria (ntm) from non-pulmonary sites over 4 years in nebraska
topic Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630832/
http://dx.doi.org/10.1093/ofid/ofx163.1792
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