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Positive Selection Linked with Generation of Novel Mammalian Dentition Patterns

A diverse group of genes are involved in the tooth development of mammals. Several studies, focused mainly on mice and rats, have provided a detailed depiction of the processes coordinating tooth formation and shape. Here we surveyed 236 tooth-associated genes in 39 mammalian genomes and tested for...

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Autores principales: Machado, João Paulo, Philip, Siby, Maldonado, Emanuel, O’Brien, Stephen J., Johnson, Warren E., Antunes, Agostinho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630915/
https://www.ncbi.nlm.nih.gov/pubmed/27613398
http://dx.doi.org/10.1093/gbe/evw200
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author Machado, João Paulo
Philip, Siby
Maldonado, Emanuel
O’Brien, Stephen J.
Johnson, Warren E.
Antunes, Agostinho
author_facet Machado, João Paulo
Philip, Siby
Maldonado, Emanuel
O’Brien, Stephen J.
Johnson, Warren E.
Antunes, Agostinho
author_sort Machado, João Paulo
collection PubMed
description A diverse group of genes are involved in the tooth development of mammals. Several studies, focused mainly on mice and rats, have provided a detailed depiction of the processes coordinating tooth formation and shape. Here we surveyed 236 tooth-associated genes in 39 mammalian genomes and tested for signatures of selection to assess patterns of molecular adaptation in genes regulating mammalian dentition. Of the 236 genes, 31 (∼13.1%) showed strong signatures of positive selection that may be responsible for the phenotypic diversity observed in mammalian dentition. Mammalian-specific tooth-associated genes had accelerated mutation rates compared with older genes found across all vertebrates. More recently evolved genes had fewer interactions (either genetic or physical), were associated with fewer Gene Ontology terms and had faster evolutionary rates compared with older genes. The introns of these positively selected genes also exhibited accelerated evolutionary rates, which may reflect additional adaptive pressure in the intronic regions that are associated with regulatory processes that influence tooth-gene networks. The positively selected genes were mainly involved in processes like mineralization and structural organization of tooth specific tissues such as enamel and dentin. Of the 236 analyzed genes, 12 mammalian-specific genes (younger genes) provided insights on diversification of mammalian teeth as they have higher evolutionary rates and exhibit different expression profiles compared with older genes. Our results suggest that the evolution and development of mammalian dentition occurred in part through positive selection acting on genes that previously had other functions.
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spelling pubmed-56309152017-11-01 Positive Selection Linked with Generation of Novel Mammalian Dentition Patterns Machado, João Paulo Philip, Siby Maldonado, Emanuel O’Brien, Stephen J. Johnson, Warren E. Antunes, Agostinho Genome Biol Evol Research Article A diverse group of genes are involved in the tooth development of mammals. Several studies, focused mainly on mice and rats, have provided a detailed depiction of the processes coordinating tooth formation and shape. Here we surveyed 236 tooth-associated genes in 39 mammalian genomes and tested for signatures of selection to assess patterns of molecular adaptation in genes regulating mammalian dentition. Of the 236 genes, 31 (∼13.1%) showed strong signatures of positive selection that may be responsible for the phenotypic diversity observed in mammalian dentition. Mammalian-specific tooth-associated genes had accelerated mutation rates compared with older genes found across all vertebrates. More recently evolved genes had fewer interactions (either genetic or physical), were associated with fewer Gene Ontology terms and had faster evolutionary rates compared with older genes. The introns of these positively selected genes also exhibited accelerated evolutionary rates, which may reflect additional adaptive pressure in the intronic regions that are associated with regulatory processes that influence tooth-gene networks. The positively selected genes were mainly involved in processes like mineralization and structural organization of tooth specific tissues such as enamel and dentin. Of the 236 analyzed genes, 12 mammalian-specific genes (younger genes) provided insights on diversification of mammalian teeth as they have higher evolutionary rates and exhibit different expression profiles compared with older genes. Our results suggest that the evolution and development of mammalian dentition occurred in part through positive selection acting on genes that previously had other functions. Oxford University Press 2016-08-18 /pmc/articles/PMC5630915/ /pubmed/27613398 http://dx.doi.org/10.1093/gbe/evw200 Text en © The Author(s) 2016. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Research Article
Machado, João Paulo
Philip, Siby
Maldonado, Emanuel
O’Brien, Stephen J.
Johnson, Warren E.
Antunes, Agostinho
Positive Selection Linked with Generation of Novel Mammalian Dentition Patterns
title Positive Selection Linked with Generation of Novel Mammalian Dentition Patterns
title_full Positive Selection Linked with Generation of Novel Mammalian Dentition Patterns
title_fullStr Positive Selection Linked with Generation of Novel Mammalian Dentition Patterns
title_full_unstemmed Positive Selection Linked with Generation of Novel Mammalian Dentition Patterns
title_short Positive Selection Linked with Generation of Novel Mammalian Dentition Patterns
title_sort positive selection linked with generation of novel mammalian dentition patterns
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630915/
https://www.ncbi.nlm.nih.gov/pubmed/27613398
http://dx.doi.org/10.1093/gbe/evw200
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