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Comparison of Antibiotic Regimens in Intra-abdominal Infections

BACKGROUND: Appropriate antimicrobial therapy and sometimes urgent surgery are life-saving in intra-abdominal infections (IAI). METHODS: We performed a retrospective case control study to evaluate the efficacy of ceftriaxone, ceftriaxone plus metronidazole, tigecycline, and ertapenem regimens in IAI...

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Autores principales: Hasanoglu, Imran, Guner, Rahmet, Bilmez, Ruveyda, Kayaaslan, Bircan, Buzgan, Turan, Tasyaran, Mehmet A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630934/
http://dx.doi.org/10.1093/ofid/ofx163.887
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author Hasanoglu, Imran
Guner, Rahmet
Bilmez, Ruveyda
Kayaaslan, Bircan
Buzgan, Turan
Tasyaran, Mehmet A
author_facet Hasanoglu, Imran
Guner, Rahmet
Bilmez, Ruveyda
Kayaaslan, Bircan
Buzgan, Turan
Tasyaran, Mehmet A
author_sort Hasanoglu, Imran
collection PubMed
description BACKGROUND: Appropriate antimicrobial therapy and sometimes urgent surgery are life-saving in intra-abdominal infections (IAI). METHODS: We performed a retrospective case control study to evaluate the efficacy of ceftriaxone, ceftriaxone plus metronidazole, tigecycline, and ertapenem regimens in IAI. Patients aged >18 years and diagnosed with IAI between 2015 and 2017 are included in the study. Definitions are based on IDSA IAI guideline. Significant resolution of all signs and symptoms of IAI with no further need for antimicrobial therapy or surgical intervention for infection is accepted as clinical response (CR). Microbiological response (MR) is assessed among patients with positive culture and defined as documented or presumptive microbiological eradication of pathogen. RESULTS: 659 patients are included in the study. Mean age was 56 years. Source control was maintained in 45.5% of patients. Among 54 patients with available culture specimen, E.coli was the most isolated pathogen (81% ESBL +). Comparisons of antibiotics in all patients and in complicated IAI are shown in Table 1 and 2, respectively. CONCLUSION: Ertapenem, and especially tigecycline are good options in IAI in the era of high antimicrobial resistance. DISCLOSURES: All authors: No reported disclosures.
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spelling pubmed-56309342017-11-07 Comparison of Antibiotic Regimens in Intra-abdominal Infections Hasanoglu, Imran Guner, Rahmet Bilmez, Ruveyda Kayaaslan, Bircan Buzgan, Turan Tasyaran, Mehmet A Open Forum Infect Dis Abstracts BACKGROUND: Appropriate antimicrobial therapy and sometimes urgent surgery are life-saving in intra-abdominal infections (IAI). METHODS: We performed a retrospective case control study to evaluate the efficacy of ceftriaxone, ceftriaxone plus metronidazole, tigecycline, and ertapenem regimens in IAI. Patients aged >18 years and diagnosed with IAI between 2015 and 2017 are included in the study. Definitions are based on IDSA IAI guideline. Significant resolution of all signs and symptoms of IAI with no further need for antimicrobial therapy or surgical intervention for infection is accepted as clinical response (CR). Microbiological response (MR) is assessed among patients with positive culture and defined as documented or presumptive microbiological eradication of pathogen. RESULTS: 659 patients are included in the study. Mean age was 56 years. Source control was maintained in 45.5% of patients. Among 54 patients with available culture specimen, E.coli was the most isolated pathogen (81% ESBL +). Comparisons of antibiotics in all patients and in complicated IAI are shown in Table 1 and 2, respectively. CONCLUSION: Ertapenem, and especially tigecycline are good options in IAI in the era of high antimicrobial resistance. DISCLOSURES: All authors: No reported disclosures. Oxford University Press 2017-10-04 /pmc/articles/PMC5630934/ http://dx.doi.org/10.1093/ofid/ofx163.887 Text en © The Author 2017. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Abstracts
Hasanoglu, Imran
Guner, Rahmet
Bilmez, Ruveyda
Kayaaslan, Bircan
Buzgan, Turan
Tasyaran, Mehmet A
Comparison of Antibiotic Regimens in Intra-abdominal Infections
title Comparison of Antibiotic Regimens in Intra-abdominal Infections
title_full Comparison of Antibiotic Regimens in Intra-abdominal Infections
title_fullStr Comparison of Antibiotic Regimens in Intra-abdominal Infections
title_full_unstemmed Comparison of Antibiotic Regimens in Intra-abdominal Infections
title_short Comparison of Antibiotic Regimens in Intra-abdominal Infections
title_sort comparison of antibiotic regimens in intra-abdominal infections
topic Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630934/
http://dx.doi.org/10.1093/ofid/ofx163.887
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