Cargando…

AAI101, a Novel β-Lactamase Inhibitor: Microbiological and Enzymatic Profiling

BACKGROUND: AAI101 is a novel β-lactamase inhibitor (BLI), active against ESBLs and other β-lactamases. AAI101 combined with cefepime (FEP) is in Phase 2 clinical trials. The objective of this study was to determine differences between AAI101 and tazobactam in their inhibition of selected β-lactamas...

Descripción completa

Detalles Bibliográficos
Autores principales:	Papp-Wallace, Krisztina M, Bethel, Christopher R, Barnes, Melissa D, Rutter, Joseph D, Taracila, Magdalena A, Bajaksouzian, Saralee, Jacobs, Michael R, Bonomo, Robert A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Abstracts
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5631055/ http://dx.doi.org/10.1093/ofid/ofx163.924

Ejemplares similares

698. Nacubactam Inhibits Class A β-lactamases
por: Barnes, Melissa D, et al.
Publicado: (2018)

The Effectiveness of Imipenem–Relebactam against Ceftazidime-Avibactam Resistant Variants of the KPC-2 β-Lactamase
por: Papp-Wallace, Krisztina M., et al.
Publicado: (2023)

The Novel β-Lactamase Inhibitor, ETX-2514, in Combination with Sulbactam Effectively Inhibits Acinetobacter baumannii
por: Barnes, Melissa D, et al.
Publicado: (2017)

1437. Biochemical characterization of L1 and L2 β-lactamases from clinical isolates of Stenotrophomonas maltophilia
por: Mojica, Maria F, et al.
Publicado: (2020)

Deciphering the Evolution of Cephalosporin Resistance to Ceftolozane-Tazobactam in Pseudomonas aeruginosa
por: Barnes, Melissa D., et al.
Publicado: (2018)

Population Structure, Molecular Epidemiology, and β-Lactamase Diversity among Stenotrophomonas maltophilia Isolates in the United States
por: Mojica, Maria F., et al.
Publicado: (2019)

Activity of the Novel Extended-spectrum β-Lactamase Inhibitor AAI101 in Combination with Cefepime Towards a Challenge Panel of Acinetobacter baumannii
por: Morrissey, Ian, et al.
Publicado: (2017)

In Vitro Activity of Cefepime/AAI101 and Comparators against Cefepime Non-susceptible Enterobacteriaceae
por: Crandon, Jared L., et al.
Publicado: (2015)

1250. Novel Boronic Acid Transition State Analogs (BATSI) with in vitro inhibitory activity against class A, B and C β-lactamases
por: Mojica, Maria F, et al.
Publicado: (2020)

Klebsiella pneumoniae Carbapenemase-2 (KPC-2), Substitutions at Ambler Position Asp179, and Resistance to Ceftazidime-Avibactam: Unique Antibiotic-Resistant Phenotypes Emerge from β-Lactamase Protein Engineering
por: Barnes, Melissa D., et al.
Publicado: (2017)

Bacterial Colonization and Antibiotic Resistance in a Prospective Cohort of Newborn Infants During the First Year of Life
por: Meropol, Sharon B., et al.
Publicado: (2016)

Targeting Multidrug-Resistant Acinetobacter spp.: Sulbactam and the Diazabicyclooctenone β-Lactamase Inhibitor ETX2514 as a Novel Therapeutic Agent
por: Barnes, Melissa D., et al.
Publicado: (2019)

Insights Into the Inhibition of MOX-1 β-Lactamase by S02030, a Boronic Acid Transition State Inhibitor
por: Ishikawa, Tatsuya, et al.
Publicado: (2021)

Novel β-lactamase inhibitors: a therapeutic hope against the scourge of multidrug resistance
por: Watkins, Richard R., et al.
Publicado: (2013)

Penicillanic Acid Sulfones Inactivate the Extended-Spectrum β-Lactamase CTX-M-15 through Formation of a Serine-Lysine Cross-Link: an Alternative Mechanism of β-Lactamase Inhibition
por: Hinchliffe, Philip, et al.
Publicado: (2022)

MJRA1.9 - AAI requirements of DCIs
Publicado: (Nove)

Inhibition of Klebsiella β-Lactamases (SHV-1 and KPC-2) by Avibactam: A Structural Study
por: Krishnan, Nikhil P., et al.
Publicado: (2015)

1256. In Vivo Activity and Structural Characterization of a New Generation γ-Lactam Siderophore Antibiotic Against Multidrug-Resistant Gram-Negative Bacteria and Acinetobacter spp
por: Goldberg, Joel, et al.
Publicado: (2020)

Genome-wide identification of GhAAI genes reveals that GhAAI66 triggers a phase transition to induce early flowering
por: Qanmber, Ghulam, et al.
Publicado: (2019)

New Insights into Dissemination and Variation of the Health Care-Associated Pathogen Acinetobacter baumannii from Genomic Analysis
por: Wright, Meredith S., et al.
Publicado: (2014)

Erratum for “New Insights into Dissemination and Variation of the Health Care-Associated Pathogen Acinetobacter baumannii from Genomic Analysis”
por: Wright, Meredith S., et al.
Publicado: (2015)

Editorial: Women and clinical microbiology 2021
por: Papp-Wallace, Krisztina M., et al.
Publicado: (2022)

AAI-powered Federated Groups for SURF Research Drive
por: de Jong, Michiel
Publicado: (2023)

de.NBI Cloud federation through ELIXIR AAI
por: Belmann, Peter, et al.
Publicado: (2019)

1432. Exploring Cell Wall Targets to Overcome Mycobacterium tuberculosis (Mtb): Ceftriaxone (CRO) Inhibits Ldt(Mt2), a Major Peptidoglycan (PG) Synthase
por: Nguyen, David C, et al.
Publicado: (2022)

Testing S3 API for OBS, and Federated AAI for HNSciCloud
por: Pintjuk, Daniil
Publicado: (2016)

1445. Deciphering the Role of the Y221H Ω-loop Substitution in Pseudomonas-derived Cephalosporinase (PDC) in Cephalosporin Resistance
por: Mack, Andrew R, et al.
Publicado: (2020)

Structures of FOX-4 Cephamycinase in Complex with Transition-State Analog Inhibitors
por: Lefurgy, Scott T., et al.
Publicado: (2020)

Editorial: Structural and Biochemical Aspects of the Interaction of β-Lactamases With State-of-the-Art Inhibitors
por: Papp-Wallace, Krisztina M., et al.
Publicado: (2022)

Surveillance of Zoonotic Parasites in Animals Involved in Animal-Assisted Interventions (AAIs)
por: Simonato, Giulia, et al.
Publicado: (2020)

Appearance Anxiety Inventory (AAI): creation and validation of the Polish language version
por: Yurtsever, Ida, et al.
Publicado: (2022)

Following Drug Uptake and Reactions inside Escherichia coli Cells by Raman Microspectroscopy
por: Heidari Torkabadi, Hossein, et al.
Publicado: (2014)

1572. Combination Cefuroxime and Sulopenem is active in vitro against Mycobacterium abscessus
por: Dousa, Khalid M, et al.
Publicado: (2020)

Boronic Acid Transition State Inhibitors as Potent Inactivators of KPC and CTX-M β-Lactamases: Biochemical and Structural Analyses
por: Alsenani, Tahani A., et al.
Publicado: (2023)

An Adaptive Alternating Magnetic Interference Suppression (AAIS) Algorithm for Geomagnetic Vector Measurement
por: Wang, Weilin, et al.
Publicado: (2022)

Development and validation of the Ukrainian version of the Academic and Athletic Identity Scale (AAIS-UA)
por: Yukhymenko-Lescroart, Mariya A., et al.
Publicado: (2023)

Durlobactam, a Broad-Spectrum Serine β-lactamase Inhibitor, Restores Sulbactam Activity Against Acinetobacter Species
por: Papp-Wallace, Krisztina M, et al.
Publicado: (2023)

Inhibiting Mycobacterium abscessus Cell Wall Synthesis: Using a Novel Diazabicyclooctane β-Lactamase Inhibitor To Augment β-Lactam Action
por: Dousa, Khalid M., et al.
Publicado: (2022)

1286. Taniborbactam Inhibits Cefepime-Hydrolyzing Variants of Pseudomonas-derived Cephalosporinase (PDC)
por: Mack, Andrew R, et al.
Publicado: (2021)

Detection of SHV β-lactamases in Gram-negative bacilli using fluorescein-labeled antibodies
por: Hujer, Andrea M, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_7uj01ohghtj8tlr3rqeeog4j21